Influence of human leukocyte antigen in the pathogenesis of Ménière's disease in the South Korean population
| Autor: | Tai-Gyu Kim, Chul-Woo Pyo, Heung-Youp Lee, Eun-Ju Jeon, Shi-Nae Park, Sang W. Yeo |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Adult
Male medicine.medical_specialty Pathology Genotype Hearing loss Hearing Loss Sensorineural Population Human leukocyte antigen HLA-C Antigens Gastroenterology Pathogenesis Gene Frequency HLA Antigens Internal medicine Medicine Humans Genetic Predisposition to Disease education Allele frequency Meniere Disease Aged education.field_of_study HLA-D Antigens Korea HLA-A Antigens business.industry General Medicine Middle Aged medicine.disease Hearing level Otorhinolaryngology HLA-B Antigens Relative risk Female medicine.symptom business Meniere's disease |
| Zdroj: | Acta oto-laryngologica. 122(8) |
| ISSN: | 0001-6489 |
| Popis: | In order to study the associations of Meniere's disease (MD) with human leukocyte antigen (HLA) alleles in the South Korean population, we examined the distribution of HLA class I and II alleles in 39 MD patients and 199 healthy controls. The frequencies of HLA-Cw*0303 (relative risk (RR) = 2.5; p < 0.02) and -Cw*0602 (RR = 3.7; p < 0.03) were significantly increased in patients with MD compared to controls. However, HLA-B44 (RR = 0.2, p < 0.004) and -Cw*0102 (RR = 0.3; p < 0.03) were significantly decreased in patients compared to controls. When the association between hearing level and the presence of HLA alleles was evaluated, the frequencies of HLA-B13 (RR = 7.4; p < 0.004), -B39 (RR = 45.7; p < 0.003), -Cw*0303 (RR = 4.5; p < 0.02) and -Cw*0602 (RR = 6.5; p < 0.02) were significantly increased and those of -B44 (RR = 0.1; p < 0.02) and -Cw*0102 (RR = 0.1; p < 0.03) were significantly decreased in MD patients with hearing losses (stages II-IV) compared to controls. The frequency of HLA-B13 was significantly higher in MD patients with hearing loss (stages II-IV) than in those with normal hearing (stage I). In terms of HLA-DRB1, -DQA1 and -DQB1 allele frequencies, a significantly higher frequency of DRB1*15 was seen in the patients (RR = 2.4; p < 0.03). These results suggest that some HLA alleles may be a useful genetic marker for predicting prognosis in South Korean patients with MD. |
| Databáze: | OpenAIRE |
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