Hypertrophy of intestinal smooth muscle in cats
| Autor: | M. Muracchini, V. Sanguinetti, Paolo Stefano Marcato, Maria Morini, L. Della Salda, Rosario Preziosi, Carlo Guglielmini, Giuliano Bettini |
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| Rok vydání: | 2003 |
| Předmět: |
Male
Pathology medicine.medical_specialty Biology Cat Diseases Enteritis Muscle hypertrophy Intestine Small medicine Animals Intestinal Mucosa CATS General Veterinary Histology Muscle Smooth Hypertrophy Hyperplasia medicine.disease Immunohistochemistry Small intestine Microscopy Electron medicine.anatomical_structure Cats Female Smooth muscle hypertrophy |
| Popis: | Pathological findings of four cats with severe and diffuse smooth muscle hypertrophy of the small intestine (MHSI) are reported and compared to those of five cats with segmental MHSI secondary to neoplastic obstruction and four controls. Histology demonstrated a constant association between idiopathic MHSI and submucosal fibrosis and chronic lymphoplasmacytic enteritis. Morphometry (gut diameter, thickness and area of muscular layers, number and density of smooth muscle nuclei) and MIB-1-immunolabelling showed that the thickness increase was mostly due to hypertrophy, but hyperplasia was also evident. Microbiology from ileal content samples was performed in two cats with primary MHSI, and Campylobacter spp. were isolated, which were also demonstrated by immunohistochemistry and ultrastructure. The association of chronic enteritis with idiopathic MHSI suggests that factors released in intestinal inflammation may also act as hypertrophy stimuli for smooth muscle cells. |
| Databáze: | OpenAIRE |
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