Carvacrol modulates instability of xenobiotic metabolizing enzymes and downregulates the expressions of PCNA, MMP-2, and MMP-9 during diethylnitrosamine-induced hepatocarcinogenesis in rats
| Autor: | Elamaran Ramasamy, Divya Mgj, Ramakrishnan Veerabathiran, Gopi Krishnan Mani, Rajan Balan, Jayakumar Subramaniyan, Devaki Thiruvengadam, Shenbhagaraman Ramalingam, Gokuladhas Krishnan, Premkumar Thandavamoorthy |
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| Rok vydání: | 2014 |
| Předmět: |
Male
Clinical Biochemistry Down-Regulation Antineoplastic Agents Matrix metalloproteinase medicine.disease_cause chemistry.chemical_compound Carcinoembryonic antigen Liver Neoplasms Experimental Proliferating Cell Nuclear Antigen medicine Biomarkers Tumor Animals Carvacrol Diethylnitrosamine Neoplasm Invasiveness Rats Wistar Molecular Biology Cell Proliferation biology Cell growth Cell Biology General Medicine Mast cell medicine.disease Proliferating cell nuclear antigen Rats Gene Expression Regulation Neoplastic medicine.anatomical_structure chemistry Matrix Metalloproteinase 9 Hepatocellular carcinoma Immunology Cancer research biology.protein Monoterpenes Cymenes Matrix Metalloproteinase 2 Carcinogenesis |
| Zdroj: | Molecular and cellular biochemistry. 395(1-2) |
| ISSN: | 1573-4919 |
| Popis: | Hepatocellular carcinoma is the fifth most common malignant tumor in the world, both in terms of incidence and mortality in Asian and Western countries. There are currently limited therapeutic regimens available for effective treatment of this cancer. Carvacrol is a predominant monoterpenoic phenol believed to impede cancer promotion and progression. The present study was conducted to decipher the role of carvacrol during diethylnitrosamine (DEN)-induced hepatocarcinogenesis in male wistar albino rats. Carvacrol (15 mg/kg body weight) suppressed the elevation of serum tumor marker enzymes, carcinoembryonic antigen, and α-feto protein induced by DEN. The activities of phase I enzymes increased markedly during DEN induction, but was found to be significantly lowered upon carvacrol treatment. On the contrary, the phase II enzymes decreased in DEN-administered animals, which was improved normalcy upon carvacrol-treated animals. DEN-administered animals showed increased mast cell counts, argyrophilic nucleolar organizing regions, proliferating cell nuclear antigen, and matrix metalloproteinases (MMPs-2/9), whereas carvacrol supplementation considerably suppressed all the above abnormalities. The results suggest that the carvacrol exhibited the potential anticancer activity by inhibiting cell proliferation and preventing metastasis in DEN-induced hepatocellular carcinogenesis. |
| Databáze: | OpenAIRE |
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