Fatal Dengue, Chikungunya and Leptospirosis: The Importance of Assessing Co-infections in Febrile Patients in Tropical Areas
| Autor: | Jesús Alberto Garzón-Ramírez, Jaime A. Cardona-Ospina, Alfonso J. Rodriguez-Morales, Juan Alexander Cerón-Pineda, Carlos Eduardo Jiménez-Canizales, Heriberto Vásquez-Serna, José Fair Alarcón-Robayo |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
myalgia medicine.medical_specialty chikungunya Leptospira 030106 microbiology 030231 tropical medicine lcsh:Medicine Case Report Colombia medicine.disease_cause Dengue fever 03 medical and health sciences 0302 clinical medicine co-infection Internal medicine Medicine Medical history Chikungunya General Immunology and Microbiology biology business.industry lcsh:R Public Health Environmental and Occupational Health virus diseases Jaundice medicine.disease biology.organism_classification Leptospirosis dengue Infectious Diseases Latin America Pulseless electrical activity medicine.symptom business Leptospira interrogans |
| Zdroj: | Tropical Medicine and Infectious Disease Tropical Medicine and Infectious Disease, Vol 3, Iss 4, p 123 (2018) |
| ISSN: | 2414-6366 |
| Popis: | The febrile patient from tropical areas, in which emerging arboviruses are endemic, represents a diagnostic challenge, and potential co-infections with other pathogens (i.e., bacteria or parasites) are usually overlooked. We present a case of an elderly woman diagnosed with dengue, chikungunya and Leptospira interrogans co-infection. Study Design: Case report. An 87-year old woman from Colombia complained of upper abdominal pain, arthralgia, myalgia, hyporexia, malaise and intermittent fever accompanied with progressive jaundice. She had a medical history of chronic heart failure (Stage C, New York Heart Association, NYHA III), without documented cardiac murmurs, right bundle branch block, non-valvular atrial fibrillation, hypertension, and chronic venous disease. Her cardiac and pulmonary status quickly deteriorated after 24 h of her admission without electrocardiographic changes and she required ventilatory and vasopressor support. In the next hours the patient evolved to pulseless electrical activity and then she died. Dengue immunoglobulin M (IgM), non-structural protein 1 (NS1) enzyme-linked immunosorbent assay (ELISA), microagglutination test (MAT) for Leptospira interrogans and reverse transcription polymerase chain reaction (RT-PCR) for chikungunya, were positive. This case illustrates a multiple co-infection in a febrile patient from a tropical area of Latin America that evolved to death. |
| Databáze: | OpenAIRE |
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