Digestive-tract sarcoidosis: French nationwide case-control study of 25 cases
| Autor: | Ghrenassia, Etienne, Mekinian, Arsene, Chapelon-Albric, Catherine, Levy, Pierre, Cosnes, Jacques, Sève, Pascal, Lefèvre, Guillaume, Dhôte, Robin, Launay, David, Prendki, Virginie, Morell-Dubois, Sandrine, Sadoun, Danielle, Mehdaoui, Anas, Soussan, Michael, Bourrier, Anne, Ricard, Laure, Benamouzig, Robert, Valeyre, Dominique, Fain, Olivier, Groupe Sarcoïdose Francophone |
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| Přispěvatelé: | CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Ecosystèmes Insulaires Océaniens (UMR 241) (EIO), Institut de Recherche pour le Développement (IRD)-Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER)-Université de la Polynésie Française (UPF)-Institut Louis Malardé [Papeete] (ILM), Institut de Recherche pour le Développement (IRD), Centre de Recherche en Cancérologie de Lyon (UNICANCER/CRCL), Centre Léon Bérard [Lyon]-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), MIGA - consortium, Service de Médecine interne A et polyclinique médicale [CHU Limoges], CHU Limoges, Groupe d'Etude de la Matière Condensée (GEMAC), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Centre National de la Recherche Scientifique (CNRS), Université Pierre et Marie Curie - Paris 6 (UPMC), Université Paris 13 (UP13), Hôpital Avicenne [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Assistance Publique - Hôpitaux de Paris, Unité de Gastroentérologie, Centre de Recherche en Nutrition Humaine, Service des maladies respiratoires, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Groupe Hospitalier Avicenne-Jean Verdier-René Muret, Service de rhumatologie [CHU Saint-Antoine], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Service de Médecine Interne [CHU Saint-Antoine], Université de la Polynésie Française (UPF)-Institut Louis Malardé [Papeete] (ILM), Institut de Recherche pour le Développement (IRD)-Institut de Recherche pour le Développement (IRD)-Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER), Service de Gastroentérologie et nutrition [CHU Saint-Antoine], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), Service de rhumatologie, inflammation-immunopathologie- biothérapie [CHU Saint-Antoine] (DHU i2B ), CHU Saint-Antoine [APHP]-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP), Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-CHU Saint-Antoine [APHP], Centre de Recherche en Cancérologie de Lyon (CRCL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre Léon Bérard [Lyon]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Hôpital Avicenne, Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Groupe Hospitalier Avicenne-Jean Verdier-René Muret |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Male
Abdominal pain diagnosis Remission Spontaneous Digestive System Diseases/diagnosis Crohn Disease/diagnosis Sarcoidosis/epidemiology Gastroenterology Cohort Studies surgery 0302 clinical medicine Crohn Disease Odds Ratio Endoscopy Digestive System Granuloma Stomach Crohn Disease/therapy General Medicine Middle Aged Sarcoidosis/diagnosis 3. Good health Diarrhea medicine.anatomical_structure 030220 oncology & carcinogenesis Vomiting Digestive System Diseases/therapy Medicine 030211 gastroenterology & hepatology Female Sarcoidosis France medicine.symptom Switzerland Adult medicine.medical_specialty Patients Nausea Colon Rectum Crohn Disease/epidemiology Sarcoidosis/therapy [SDV.CAN]Life Sciences [q-bio]/Cancer Diagnosis Differential 03 medical and health sciences Young Adult Ileum Internal medicine medicine Humans Esophagus Aged business.industry Endoscopy medicine.disease Abdominal Pain Cross-Sectional Studies Digestive System Diseases/epidemiology Case-Control Studies ddc:618.97 business |
| Zdroj: | Medicine Medicine, 2016, 95, pp.e4279. ⟨10.1097/MD.0000000000004279⟩ Medicine (Baltimore), Vol. 95, No 29 (2016) P. e4279 Medicine, Lippincott, Williams & Wilkins, 2016, 95, pp.e4279. ⟨10.1097/MD.0000000000004279⟩ |
| ISSN: | 0025-7974 1536-5964 |
| DOI: | 10.1097/MD.0000000000004279⟩ |
| Popis: | International audience; Digestive tract sarcoidosis (DTS) is rare and case-series are lacking. In this retrospective case-control study, we aimed to compare the characteristics, outcome, and treatment of patients with DTS, nondigestive tract sarcoidosis (NDTS), and Crohn disease.We included cases of confirmed sarcoidosis, symptomatic digestive tract involvement, and noncaseating granuloma in any digestive tract. Each case was compared with 2 controls with sarcoidoisis without digestive tract involvement and 4 with Crohn disease.We compared 25 cases of DTS to 50 controls with NDTS and 100 controls with Crohn disease. The major digestive clinical features were abdominal pain (56%), weight loss (52%), nausea/vomiting (48%), diarrhea (32%), and digestive bleeding (28%). On endoscopy of DTS, macroscopic lesions were observed in the esophagus (9%), stomach (78%), duodenum (9%), colon, (25%) and rectum (19%). As compared with NDTS, DTS was associated with weight loss (odds ratio [OR] 5.8; 95% confidence interval [CI] 1.44-23.3) and the absence of thoracic adenopathy (OR 5.0; 95% CI 1.03-25). As compared with Crohn disease, DTS was associated with Afro-Caribbean origin (OR 27; 95% CI 3.6-204) and the absence of ileum or colon macroscopic lesions (OR 62.5; 95% CI 10.3-500). On the last follow-up, patients with DTS showed no need for surgery (versus 31% for patients with Crohn disease; P = 0.0013), and clinical digestive remission was frequent (76% vs. 35% for patients with Crohn disease; P = 0.0002).The differential diagnosis with Crohn disease could be an issue with DTS. Nevertheless, the 2 diseases often have different clinical presentation and outcome |
| Databáze: | OpenAIRE |
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