Effect of a gum-based thickener on the safety of swallowing in patients with poststroke oropharyngeal dysphagia
| Autor: | Mireia Bolivar-Prados, Omar Ortega Fernández, Natàlia Vilardell, Alberto Martín, Pere Clavé, Viridiana Arreola, Sonia Guida, Dina Ripken, Laia Rofes, Mirian Lansink, Weslania Viviane Nascimento |
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| Rok vydání: | 2019 |
| Předmět: |
Male
030309 nutrition & dietetics Physiology swallow response Gastroenterology Spiration 0302 clinical medicine Bolus (medicine) Shear viscosity Medicine Single-Blind Method 0303 health sciences Viscosity Polysaccharides Bacterial xanthan gum Respiratory Aspiration thickener stroke Deglutition disorders Stroke medicine.anatomical_structure Female Original Article medicine.symptom medicine.drug medicine.medical_specialty Laryngeal vestibule shear viscosity 03 medical and health sciences Swallowing Internal medicine Humans In patient Pharyngeal Residue Aged Xanthan gum aspiration Endocrine and Autonomic Systems business.industry Therapeutic effect deglutition disorders Original Articles Deglutition Swallow response Thickener business 030217 neurology & neurosurgery Oropharyngeal dysphagia |
| Zdroj: | Dipòsit Digital de Documents de la UAB Universitat Autònoma de Barcelona Neurogastroenterology and Motility |
| Popis: | Background Increasing viscosity with thickening agents is a valid therapeutic strategy for oropharyngeal dysphagia (OD). To assess the therapeutic effect of a xanthan gum‐based thickener (Nutilis Clear®) at six viscosities compared with thin liquid in poststroke OD (PSOD) patients. Methods A total of 120 patients with PSOD were studied in this controlled, multiple‐dose, fixed‐order, and single‐blind study using videofluoroscopy (VFSS). A series of boluses of 10 mL thin liquid and 2000, 1400, 800, 450, 250, and 150 mPa s viscosities were given in duplicate, interrupted in case of aspiration. We assessed the safety and efficacy of swallow and the kinematics of the swallow response. Key Results A total of 41.2% patients had safe swallow at thin liquid which significantly increased for all viscosities from 71.9% at 150 mPa s to 95.6% at 1400 mPa s (P This study shows a strong therapeutic effect of a gum‐based thickener on safety of swallow in post‐stroke dysphagia that depends on shear viscosity levels, and a therapeutic range of 150‐800 mPa s. Increasing viscosity shortened time to laryngeal vestibule closure at all viscosities and reduced bolus velocity at ≥450 mPa s. |
| Databáze: | OpenAIRE |
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