Impact of liver steatosis on the antiviral response in the hepatitis C virus-associated chronic hepatitis
| Autor: | S. Tripi, Giuseppe Montalto, Maurizio Soresi, A. Alessandri, Vito Franco, Lydia Giannitrapani, Francesca Rappa, O. Vuturo |
|---|---|
| Přispěvatelé: | SORESI M, TRIPI S, FRANCO V, GIANNITRAPANI L, ALESSANDRI A, RAPPA F, VUTURO O, MONTALTO G |
| Rok vydání: | 2006 |
| Předmět: |
Adult
Male medicine.medical_specialty Pathology Aging Combination therapy Genotype Hepatitis C virus antiviral treatment Hepacivirus Interferon alpha-2 Single Center medicine.disease_cause Gastroenterology Antiviral Agents Severity of Illness Index Body Mass Index Polyethylene Glycols liver steatosis chemistry.chemical_compound Pegylated interferon Internal medicine Ribavirin medicine chronic hepatitis C Humans Aspartate Aminotransferases Hepatology business.industry Interferon-alpha Alanine Transaminase gamma-Glutamyltransferase Hepatitis C Chronic Middle Aged medicine.disease Recombinant Proteins Fatty Liver Treatment Outcome chemistry Liver Drug Therapy Combination Female Steatosis business Body mass index medicine.drug |
| Zdroj: | Liver international : official journal of the International Association for the Study of the Liver. 26(9) |
| ISSN: | 1478-3223 |
| Popis: | Background/Aim: Liver steatosis (LS) has been variably associated with chronic hepatitis C (CHC) but whether it affects sustained virological response to antiviral treatment and by what mechanisms is a question still under debate, at least for some genotypes. The aim of this work was to assess the frequency of LS, its relationship with host and viral factors and to what extent it can influence the response to antiviral combination therapy with pegylated interferon (INF)+ribavirin in a group of patients with CHC from a single center. Patients: One hundred and twelve patients with histologically proven CHC were treated with Peg INF-α 2a 180 μg a week subcutaneously for 48 weeks plus ribavirin 1000 or 1200 mg/day, according to the patient's body weight. Steatosis was graded according to Brunt et al. Results: Forty-six out of 112 patients (41.1%) were sustained virological responders (SVR). Seventy-two out of 112 (64.3%) presented with LS at histology; in this group, there were 24 patients (33.3%) with SVR compared with 22 (55%) of the non-steatosis group (χ2=6.5, P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|