Poor Postnatal Weight Growth is a Late Finding After Sepsis in Very Preterm Infants
| Autor: | Erik Jensen, Dustin Flannery, Faizah Bhatti, YINXI YU, Lauren Tomlinson, Alina Dumitrescu, Levi Bonnell |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty Canada Gestational Age Article Sepsis Cohort Studies 03 medical and health sciences 0302 clinical medicine Matched cohort Growth restriction 030225 pediatrics Weight growth medicine Birth Weight Humans Infant Very Low Birth Weight Neonatology Retrospective Studies business.industry Significant difference Infant Newborn Obstetrics and Gynecology Infant Retinopathy of prematurity General Medicine medicine.disease Failure to Thrive Very preterm Child Preschool Pediatrics Perinatology and Child Health 030221 ophthalmology & optometry Body-Weight Trajectory Female Neonatal Sepsis business Infant Premature |
| Zdroj: | Arch Dis Child Fetal Neonatal Ed |
| Popis: | ObjectiveTo characterise the association between sepsis and postnatal weight growth when accounting for the degree of growth restriction present at birth.DesignRetrospective matched cohort study using data from the Postnatal Growth and Retinopathy of Prematurity study. Participants were born with birth weights of ResultsOf 4785 eligible infants, 813 (17%) developed sepsis and 693 (85%) were matched 1:1 to controls. Sepsis was associated with a greater decline in weight z-score (mean difference −0.09, 95% CI −0.14 to −0.03). Postnatal weight growth failure (decline in weight z- score>1) was present in 237 (34%) infants with sepsis and 179 (26%) controls (adjusted OR 1.49, 95% CI 1.12 to 1.97). Longitudinal growth trajectories showed similar initial changes in weight z-scores between infants with and without sepsis. By 3 weeks after sepsis onset, there was a greater decline in weight z-scores relative to birth values in those with sepsis than without sepsis (delta z-score −0.89 vs −0.77; mean difference −0.12, 95% CI −0.18 to −0.05). This significant difference persisted until 36 weeks or discharge.ConclusionInfants with sepsis had similar early weight growth trajectories as infants without sepsis but developed significant deficits in weight that were not apparent until several weeks after the onset of sepsis. |
| Databáze: | OpenAIRE |
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