Determination of a fragment of the c-erbB-2 translational product p185 in serum of breast cancer patients
| Autor: | H. J. Schmoll, Alfred Schauer, Barbara Zoll, L. Binder, B. Kynast, D. Marx, M. Oellerich |
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| Rok vydání: | 1993 |
| Předmět: |
Cancer Research
medicine.medical_specialty Receptor ErbB-2 Mammary gland Breast Neoplasms Pilot Projects Gastroenterology Metastasis Gene product Immunoenzyme Techniques Breast cancer Internal medicine Proto-Oncogene Proteins medicine Biomarkers Tumor Humans Hematology medicine.diagnostic_test business.industry General Medicine Reference Standards medicine.disease Primary tumor Immunohistochemistry Peptide Fragments medicine.anatomical_structure Endocrinology Oncology Immunoassay Protein Biosynthesis Female business |
| Zdroj: | Journal of cancer research and clinical oncology. 119(5) |
| ISSN: | 0171-5216 |
| Popis: | Concentrations of a fragment of the c-erbB-2 translational product (p185 fragment) were measured in serum of 70 breast cancer patients, 19 healthy blood donors, and 18 pregnant women using a heterogenic enzyme immunoassay. The serum concentrations of blood donors and pregnant women were below 30 kU/l. Breast cancer patients showed serum concentrations up to 578 kU/l. All 9/70 patients with serum concentrations higher than 30 kU/l had clinical evidence of metastatic disease and the serum levels of all 35/70 patients without metastasis lay within the normal range. From 9/37 patients with p185 overexpression of the primary tumor in immunohistochemical analysis 3/9 patients with metastatic disease had elevated serum levels higher than 30 kU/l. In all, 6/9 patients without metastasis serum levels were below 30 kU/l. The data of the present study suggest that determination of serum p185 fragment concentrations may be useful as a diagnostic tool in postoperative follow-up of breast cancer patients with c-erbB-2 overexpression of the primary tumor. |
| Databáze: | OpenAIRE |
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