Correlation of Clinical and Immunologic Parameters of the Inflammatory Activity of Pulmonary Sarcoidosis
| Autor: | Sibylle Pfeifer, Ferlinz R, János Strausz, J. Müller-Quernheim |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Adult
Lung Diseases Male Pulmonary and Respiratory Medicine Systemic disease Sarcoidosis T-Lymphocytes Lymphocyte CD4-CD8 Ratio Enzyme-Linked Immunosorbent Assay Inflammation Lymphocyte Activation Humans Medicine Receptor medicine.diagnostic_test business.industry Respiratory disease Receptors Interleukin-2 HLA-DR Antigens respiratory system medicine.disease respiratory tract diseases Bronchoalveolar lavage medicine.anatomical_structure Immunology Interleukin-2 Female medicine.symptom business Bronchoalveolar Lavage Fluid |
| Zdroj: | American Review of Respiratory Disease. 144:1322-1329 |
| ISSN: | 0003-0805 |
| DOI: | 10.1164/ajrccm/144.6.1322 |
| Popis: | The evaluation of activation markers such as T4/T8 ratio and HLA-DR expression of lymphocytes of bronchoalveolar lavage (L-BAL) is an important clinical approach for the staging of sarcoidosis. However, it is not known to what extent this is paralleled by an exaggerated lymphocyte function. We investigated the dependence of L-BAL activation markers on the production of interleukin-2 (IL-2) by L-BAL and on the soluble IL-2 receptor serum level (sIL-2R) in 116 patients with sarcoidosis. In none of the combinations tested was a correlation between the two groups of parameters found; r less than 0.5, upper 90% confidence limit of r less than 0.8. Interestingly, IL-2 production is independent of HLA-DR+ T4 L-BAL, and sIL-2R production is independent of the percentage of IL-2+ L-BAL. Our data indicate that the L-BAL activation markers and the functional activity of T-cells represent independent phenomena. |
| Databáze: | OpenAIRE |
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