Vitamin D Status and Kidney Function Decline in HIV-Infected Men: A Longitudinal Study in the Multicenter AIDS Cohort Study
| Autor: | Long Zhang, Andrew N. Hoofnagle, Lisa P. Jacobson, Alison G. Abraham, Michelle M. Estrella, Adrienne Tin, Casey M. Rebholz, Frank J. Palella, Lawrence A. Kingsley, Mallory D. Witt, Todd T. Brown |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Male Longitudinal study Kidney Disease Multicenter AIDS Cohort Study vitamin D HIV Infections Disease Pathogenesis Kidney Function Tests Gastroenterology 0302 clinical medicine Medicine 030212 general & internal medicine Longitudinal Studies education.field_of_study glomerular filtration rate 25(OH)D Blacks Middle Aged Infectious Diseases 25(OH)2D Cohort HIV/AIDS Adult medicine.medical_specialty Immunology Population Clinical Sciences Renal and urogenital Renal function Black People White People 03 medical and health sciences Clinical Research Internal medicine Virology Complementary and Integrative Health Vitamin D and neurology Humans AIDS-Associated Nephropathy education Nutrition kidney function decline business.industry Whites Prevention medicine.disease Vitamin D Deficiency United States 030104 developmental biology Endocrinology 25(OH)(2)D business Kidney disease |
| Zdroj: | AIDS research and human retroviruses, vol 33, iss 11 |
| ISSN: | 1931-8405 |
| Popis: | Vitamin D may play an important role in a range of disease processes. In the general population, lower vitamin D levels have been associated with kidney dysfunction. HIV-infected populations have a higher risk of chronic kidney disease. Few studies have examined the link between lower vitamin D levels and kidney function decline among HIV-infected persons. We investigated the associations of serum 25-hydroxyvitamin D [25(OH)D] and 1,25-dihydroxyvitamin D [1,25(OH)2D] with kidney function decline in a cohort of HIV-infected white and black men under highly active antiretroviral therapy treatment in the vitamin D ancillary study of the Multicenter AIDS Cohort Study. The associations of 25(OH)D and 1,25(OH)2D with annual change in estimated glomerular filtration rate (eGFR) were evaluated using linear mixed effects models. This study included 187 whites and 86 blacks with vitamin D measures and eGFR ≥60 ml/min/1.73 m2 at baseline. Over a median follow-up of 8.0 years, lower 25(OH)D levels were significantly associated with faster eGFR decline in whites (adjusted annual change in eGFR, tertile 1: -2.06 ml/min/1.73 m2 vs. tertile 3: -1.23 ml/min/1.73 m2, p trend .03), while no significant association was detected in blacks. Lower 1,25(OH)2D was associated with faster kidney function decline in both whites and blacks, although the estimates were not statistically significant. In conclusion, lower 25(OH)D levels were significantly associated with faster eGFR decline in a cohort of HIV-infected white men, but not in those with black ancestry. Further research is warranted to investigate the association of 25(OH)D and 1,25(OH)2D with kidney function decline in larger and ethnically diverse populations. |
| Databáze: | OpenAIRE |
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