Detection of new 7-O-acyl derivatives of diarrhetic shellfish poisoning toxins by liquid chromatography-mass spectrometry
| Autor: | Tt. Hu, Michael A. Quilliam, S. Pleasance, Jeffrey L. C. Wright, J. C. Marr |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 1992 |
| Předmět: |
Diarrhea
Magnetic Resonance Spectroscopy Acylation ved/biology.organism_classification_rank.species Dinophysis acuta Toxicology Mass spectrometry High-performance liquid chromatography Mass Spectrometry Hydrolysis chemistry.chemical_compound Ethers Cyclic Liquid chromatography–mass spectrometry Okadaic Acid Animals Vasoconstrictor Agents Pyrans Shellfish Chromatography biology Chemistry ved/biology Okadaic acid biology.organism_classification Mytilus Bivalvia Marine Toxins Spectrophotometry Ultraviolet Chromatography Thin Layer Diarrhetic shellfish poisoning Chromatography Liquid |
| Popis: | A novel method for the detection of acylated diarrhetic shellfish poisoning toxins is reported. Direct determination of these compounds is possible using high performance liquid chromatography coupled with ion-spray mass spectrometry. An extract, purified from the digestive glands of toxic mussels (Mytilus edulis) contaminated with okadaic acid, dinophysistoxin-1, and a recently reported analog, dinophysistoxin-2, was also shown to contain small amounts of dinophysistoxin-3, a mixture of 7-O-acyl ester derivatives of dinophysistoxin-1. In addition, acyl ester derivatives of okadaic acid and dinophysistoxin-2 were also detected by direct LC-MS analysis and confirmed by analysis of their hydrolysis products. This is the first report of the detection of other naturally occurring 7-O-acyl esters similar to dinophysistoxin-3. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|