Dairy consumption, systolic blood pressure, and risk of hypertension : Mendelian randomization study
| Autor: | Ding, Ming, Huang, Tao, Bergholdt, Helle K. M., Nordestgaard, Borge G., Ellervik, Christina, Qi, Lu, Frazier-Wood, Alexis C., Aslibekyan, Stella, North, Kari E., Voortman, Trudy, Graff, Mariaelisa, Smith, Caren E., Lai, Chao-Qiang, Varbo, Anette, Lemaitre, Rozenn N., de Jonge, Ester A. L., Fumeron, Frederic, Corella, Dolores, Wang, Carol A., Tjonneland, Anne, Overvad, Kim, Sorensen, Thorkild I. A., Feitosa, Mary F., Wojczynski, Mary K., Kahonen, Mika, Ahmad, Shafqat, Renström, Frida, Psaty, Bruce M., Siscovick, David S., Barroso, Ines, Johansson, Ingegerd, Hernandez, Dena, Ferrucci, Luigi, Bandinelli, Stefania, Linneberg, Allan, Sandholt, Camilla Helene, Pedersen, Oluf, Hansen, Torben, Schulz, Christina-Alexandra, Sonestedt, Emily, Orho-Melander, Marju, Chen, Tzu-An, Rotter, Jerome I., Allison, Mathew A., Rich, Stephen S., Sorli, Jose V., Coltell, Oscar, Pennell, Craig E., Eastwood, Peter R., Hofman, Albert, Uitterlinden, Andre G., Zillikens, MCarola, van Rooij, Frank J. A., Chu, Audrey Y., Rose, Lynda M., Ridker, Paul M., Viikari, Jorma, Raitakari, Olli, Lehtimaki, Terho, Mikkila, Vera, Willett, Walter C., Wang, Yujie, Tucker, Katherine L., Ordovas, Jose M., Kilpelainen, Tuomas O., Province, Michael A., Franks, Paul W., Arnett, Donna K., Tanaka, Toshiko, Toft, Ulla, Ericso, Ulrika, Franco, Oscar H., Mozaffarian, Dariush, Hu, Frank B., Chasman, Daniel I. |
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| Přispěvatelé: | Department of Food and Nutrition, University of Helsinki |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_treatment
Blood Pressure Review 030204 cardiovascular system & hematology Corrections law.invention 0302 clinical medicine MILK Randomized controlled trial law GENETIC-VARIANTS Cardiac and Cardiovascular Systems 030212 general & internal medicine Prospective cohort study METABOLIC SYNDROME Lactase Randomized Controlled Trials as Topic 2. Zero hunger Kardiologi Nutrition and Dietetics General Medicine 16. Peace & justice 3. Good health CONTROLLED-TRIALS Näringslära Observational Studies as Topic BODY-WEIGHT CARDIOVASCULAR-DISEASE Hypertension 3143 Nutrition medicine.medical_specialty Polymorphism Single Nucleotide 03 medical and health sciences Internal medicine Mendelian randomization medicine Journal Article Humans Genetic Predisposition to Disease business.industry INCIDENT HYPERTENSION Research Odds ratio ADULTS Feeding Behavior ta3121 Mendelian Randomization Analysis Confidence interval Surgery Lactase persistence Blood pressure FAT 3121 General medicine internal medicine and other clinical medicine DOSE-RESPONSE METAANALYSIS Dairy Products business Meta-Analysis |
| Zdroj: | The BMJ Ding, M, Huang, T, Bergholdt, H K M, Sørensen, T I A, Linneberg, A R, Sandholt, C H, Pedersen, O, Hansen, T, Kilpeläinen, T O, CHARGE Consortium, Nordestgaard, B G, Ellervik, C, Qi, L & Mendelian Randomization of Dairy Consumption Working Group 2017, ' Dairy consumption, systolic blood pressure, and risk of hypertension : Mendelian randomization study ', The BMJ, vol. 356, j1000 . https://doi.org/10.1136/bmj.j1000 Ding, M, Huang, T, Bergholdt, H K, Nordestgaard, B G, Ellervik, C, Qi, L & CHARGE Consortium (Kim Overvad; member) 2017, ' Dairy consumption, systolic blood pressure, and risk of hypertension : Mendelian randomization study ', B M J (Online), vol. 356, pp. j1000 . https://doi.org/10.1136/bmj.j1000 |
| DOI: | 10.1136/bmj.j1000 |
| Popis: | Objective To examine whether previous observed inverse associations of dairy intake with systolic blood pressure and risk of hypertension were causal. Design Mendelian randomization study using the single nucleotide polymorphism rs4988235 related to lactase persistence as an instrumental variable. Setting CHARGE (Cohorts for Heart and Aging Research in Genomic Epidemiology) Consortium. Participants Data from 22 studies with 171 213 participants, and an additional 10 published prospective studies with 26 119 participants included in the observational analysis. Main outcome measures The instrumental variable estimation was conducted using the ratio of coefficients approach. Using meta-analysis, an additional eight published randomized clinical trials on the association of dairy consumption with systolic blood pressure were summarized. Results Compared with the CC genotype (CC is associated with complete lactase deficiency), the CT/TT genotype (TT is associated with lactose persistence, and CT is associated with certain lactase deficiency) of LCT-13910 (lactase persistence gene) rs4988235 was associated with higher dairy consumption (0.23 (about 55 g/day), 95% confidence interval 0.17 to 0.29) serving/day; P |
| Databáze: | OpenAIRE |
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