Risk Factors and Mouse Models of Abdominal Aortic Aneurysm Rupture
| Autor: | Susan K. Morton, Smriti M. Krishna, Jonathan Golledge, Jiaze Li |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
preclinical imaging Review 030204 cardiovascular system & hematology environment and public health rupture risk lcsh:Chemistry Aortic aneurysm Mice 0302 clinical medicine Risk Factors Aorta Abdominal lcsh:QH301-705.5 Spectroscopy Cause of death Models Cardiovascular General Medicine Abdominal aortic aneurysm Computer Science Applications Biomechanical Phenomena Cardiology cardiovascular system Aortic stiffness medicine.medical_specialty aortic stiffness Aortic Rupture peak wall stress macromolecular substances Catalysis Inorganic Chemistry 03 medical and health sciences Aneurysm abdominal aortic aneurysm medicine.artery Internal medicine medicine Animals Humans Computer Simulation cardiovascular diseases Physical and Theoretical Chemistry Aortic rupture Molecular Biology Aorta Organic Chemistry aneurysm rupture medicine.disease Aortic wall Disease Models Animal enzymes and coenzymes (carbohydrates) 030104 developmental biology lcsh:Biology (General) lcsh:QD1-999 Stress Mechanical Aortic Aneurysm Abdominal |
| Zdroj: | International Journal of Molecular Sciences, Vol 21, Iss 7250, p 7250 (2020) International Journal of Molecular Sciences |
| ISSN: | 1661-6596 1422-0067 |
| Popis: | Abdominal aortic aneurysm (AAA) rupture is an important cause of death in older adults. In clinical practice, the most established predictor of AAA rupture is maximum AAA diameter. Aortic diameter is commonly used to assess AAA severity in mouse models studies. AAA rupture occurs when the stress (force per unit area) on the aneurysm wall exceeds wall strength. Previous research suggests that aortic wall structure and strength, biomechanical forces on the aorta and cellular and proteolytic composition of the AAA wall influence the risk of AAA rupture. Mouse models offer an opportunity to study the association of these factors with AAA rupture in a way not currently possible in patients. Such studies could provide data to support the use of novel surrogate markers of AAA rupture in patients. In this review, the currently available mouse models of AAA and their relevance to the study of AAA rupture are discussed. The review highlights the limitations of mouse models and suggests novel approaches that could be incorporated in future experimental AAA studies to generate clinically relevant results. |
| Databáze: | OpenAIRE |
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