Effects of triclosan in breast milk on the infant fecal microbiome

Autor: Karen M. Kalanetra, Jennifer T. Smilowitz, J. Bruce German, Malin L. Nording, Amy A. Rand, Diana H. Taft, Bruce D. Hammock, Melissa A. Breck, David A. Mills, Candace S. Bever
Rok vydání: 2018
Předmět:
0301 basic medicine
Environmental Engineering
Breast milk
Health
Toxicology and Mutagenesis
Urine
010501 environmental sciences
01 natural sciences
Article
03 medical and health sciences
chemistry.chemical_compound
Feces
fluids and secretions
Anti-Infective Agents
Adverse health effect
Clinical Research
Breast Cancer
Environmental Chemistry
Meteorology & Atmospheric Sciences
Humans
Microbiome
Food science
0105 earth and related environmental sciences
Cancer
Nutrition
Pediatric
Bacteria
Milk
Human
Microbiota
Public Health
Environmental and Occupational Health
Infant
General Medicine
General Chemistry
Antimicrobial
Pollution
Triclosan
030104 developmental biology
Milk
chemistry
Local
Personal care products
Anti-Infective Agents
Local
Fecal microbiome
Extraction methods
Female
Environmental Sciences
Human
Zdroj: Chemosphere. 203
ISSN: 1879-1298
Popis: Triclosan is frequently used for its antimicrobial properties and has been detected in human serum, urine, and breast milk. Animal and molecular studies have shown that triclosan exerts a wide range of adverse health effects at both high (ppm) and low (ppb) concentrations. Since triclosan is of growing concern to human and environmental health, there is a need to improve extraction procedures and to study additional effects from triclosan exposure. In this study, we have improved triclosan extraction from breast milk by using salt (MgSO(4)) to reduce emulsion formation and increase water polarity and water (~80%) to enhance the overall extraction efficiency (~3.5 fold). This extraction method was applied to breast milk samples collected from donors who i) recorded their use of triclosan-containing personal care products and ii) provided matching infant stool samples. Of the participants who had detectable amounts of triclosan in their breast milk, nine (75%) of them reported daily use of triclosan-containing personal care products. Levels of triclosan in breast milk were compared to the donor’s infant’s fecal microbiome. We found that the bacterial diversity in the fecal microbiome of the infants exposed to breast milk with detectable triclosan levels differed compared to their peers exposed to milk containing non-detectable amounts. This finding implies that exogenous chemicals are impacting microbiome diversity.
Databáze: OpenAIRE
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