Leukemic Leptomeningeal Involvement in Stage 0 and Stage 1 Chronic Lymphocytic Leukemia
| Autor: | Anand Jillella, M. Majmundar, Russell Burgess, W. G. Brick, Linda Hendricks, Andre M. Kallab |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Male
Oncology Cancer Research medicine.medical_specialty Pathology Hydrocortisone Chronic lymphocytic leukemia Encephalopathy Central nervous system Leukemic Infiltration hemic and lymphatic diseases Internal medicine Meningeal Neoplasms medicine Humans Stage (cooking) Injections Spinal Aged Neoplasm Staging Diplopia Brain Diseases business.industry Hematology medicine.disease Leukemia Lymphocytic Chronic B-Cell Methotrexate Treatment Outcome medicine.anatomical_structure medicine.symptom business medicine.drug |
| Zdroj: | Leukemia & Lymphoma. 43:199-201 |
| ISSN: | 1029-2403 1042-8194 |
| DOI: | 10.1080/10428190210191 |
| Popis: | Central nervous system (CNS) involvement in early (Rai Stage 0 and Stage 1) chronic lymphocytic leukemia (CLL) is rare, with only five cases reported. We present the sixth reported case, a 77-year-old male with a 4 year history of Stage 0 CLL who presented with sudden onset of diplopia and headache. Workup revealed a leukemic involvement of his CNS and he responded well to treatment with intrathecal (IT) methotrexate. After his third IT treatment, he developed a change in his mental status, consistent with a chemotherapy induced encephalopathy, which was effectively treated with IT hydrocortisone. In addition to the case presentation, we review the previously reported cases in an effort to determine any characteristics common among the Stage 0/1 CLL patients with reported CNS involvement. |
| Databáze: | OpenAIRE |
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