Persistent symptoms of fatigue, neuropathy and role‐functioning impairment among indolent non‐Hodgkin lymphoma survivors

Autor: Afke Ekels, Lonneke V. van de Poll‐Franse, Eduardus F. M. Posthuma, Jacobien Kieffer, Djamila E. Issa, Adrianus Koster, Marten R. Nijziel, Johannes H. F. M. Pruijt, Wendy B. C. Stevens, Lidwine W. Tick, Simone Oerlemans
Přispěvatelé: Medical and Clinical Psychology
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: British Journal of Haematology, 197, 590-601
British Journal of Haematology, 197(5), 590-601. Wiley-Blackwell
British Journal of Haematology, 197, 5, pp. 590-601
ISSN: 1365-2141
0007-1048
DOI: 10.1111/bjh.18139
Popis: Item does not contain fulltext Little is known about the long-term health-related quality of life (HRQoL) and persistence of symptoms among patients with indolent non-Hodgkin lymphoma (iNHL). This large population-based longitudinal study therefore investigated the long-term HRQoL and persistence of symptoms and identified associated sociodemographic, clinical and psychological factors. Patients diagnosed between 1999 and 2014 and four or more months after diagnosis were invited to participate in a longitudinal survey. Sociodemographic and clinical data were obtained from the Netherlands Cancer Registry. The EORTC QLQ-C30 and CLL-16 were completed by 669 patients (74% response rate). Patients completed on average four questionnaires. Primary treatment was active surveillance (52%), systemic therapy (31%) or radiotherapy (13%). Respectively, 36% reported persistent fatigue, 33% persistent neuropathy and 25% persistent role-functioning impairment. This was 2-3 times higher than in the age- and sex-matched normative population. Up to 10 years after diagnosis, scores remained relatively stable without clinically relevant changes. Comorbidities, psychological distress, shorter time since diagnosis, systemic therapy, younger age, education level and having no partner were associated with worse outcomes (all ps
Databáze: OpenAIRE
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