Synthetic studies toward MPC1001: preparation of a β-hydroxyl-tyrosine derivative

Autor:	Paul T. Schuber, Robert M. Williams
Rok vydání:	2012
Předmět:	chemistry.chemical_classification Acid derivative Natural product Organic Chemistry Enantioselective synthesis Biochemistry Combinatorial chemistry Article Amino acid chemistry.chemical_compound chemistry Aldol reaction Drug Discovery Tyrosine Derivative (chemistry)
Zdroj:	Tetrahedron Letters. 53:380-382
ISSN:	0040-4039
DOI:	10.1016/j.tetlet.2011.11.069
Popis:	A procedure for the asymmetric synthesis of a novel β-hydroxy-α-amino acid deriverative to be used in the preparation of the natural product MPC1001 and analogs has been developed. The amino acid was efficiently prepared in six steps via a Mukaiyama aldol reaction via a diphenyloxazinone and 3-bromo-4-methoxybenzaldehyde.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7019a8d800dfa04355236d47b3fa88a https://doi.org/10.1016/j.tetlet.2011.11.069 Zobrazit plný text záznamu Full Text from ScienceDirect