Posttransfusion purpura. Report of a case with anti-P1A1 masked by HLA antibodies
| Autor: | Rosse Wf, Dunstan Ra |
|---|---|
| Rok vydání: | 1985 |
| Předmět: |
Blood Platelets
Blood transfusion medicine.drug_class medicine.medical_treatment Immunology Platelet Membrane Glycoproteins Platelet membrane glycoprotein Monoclonal antibody Antibody Specificity HLA Antigens Isoantibodies medicine Humans Immunology and Allergy Hla antibodies Platelet Purpura Aged Glycoproteins biology business.industry Membrane Proteins Transfusion Reaction Posttransfusion Purpura Hematology Blot biology.protein Female Antibody business |
| Zdroj: | Transfusion. 25:219-222 |
| ISSN: | 1537-2995 0041-1132 |
| Popis: | A case of posttransfusion purpura is reported in which the laboratory determination of the specificity of the causative antibody was initially confused by the presence in the patient's serum of HLA-directed antibodies. The patient was a multiparous 65-year-old woman with a previous history of blood transfusion. She developed the typical clinical features of posttransfusion purpura 8 days following the transfusion of 6 units of packed red cells. The patient was P1A1 negative, and her serum reacted strongly in a radiolabeled monoclonal antibody assay with both P1A1-positive and -negative platelets. Radioimmunoprecipitation demonstrated that the patient's serum contained antibodies both of anti-P1A1 and anti-HLA specificity. Western blotting of normal platelets incubated with the patient's serum verified that the anti-P1A1 antibody was directed against platelet membrane glycoprotein III. |
| Databáze: | OpenAIRE |
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