Inflammation across universal definition of heart failure stages: the CASABLANCA study

Autor: Mohebi, R., Liu, Y, Kimmenade, R.R.J. van, Gaggin, H.K., Murphy, S.P., Januzzi, J.L., Jr.
Rok vydání: 2023
Předmět:
Zdroj: European Journal of Heart Failure, 25, 2, pp. 152-160
European Journal of Heart Failure, 25, 152-160
ISSN: 1388-9842
Popis: Item does not contain fulltext AIM: We sought to investigate the association of inflammatory biomarkers with incident heart failure (HF) events in patients at different stages of HF. METHODS AND RESULTS: Overall, 1231 study participants undergoing diagnostic coronary and/or peripheral angiography were categorized by Universal Definition of HF (UDHF) stage A (at risk), stage B (pre-HF), and stages C or D (HF, including end-stage). Twenty-four inflammatory biomarkers were collected prior to angiography and unsupervised machine learning categorized levels of inflammation into three groups (low, medium, and high). Cox proportional hazard regression was implemented to assess the associations of inflammation level with incident HF hospitalization in each UDHF stage. Using machine learning, study participants were grouped into low (n = 443), medium (n = 570) and high inflammation categories (n = 230). Significantly higher concentrations of natriuretic peptide, troponin, and soluble ST2 were observed among those with high inflammation levels (p
Databáze: OpenAIRE
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