Lymphoblastic transformation of chronic myelomonocytic leukemia in an infant
| Autor: | Aiichiro Tanaka, Hiroyoshi Wada, Masuji Yamamoto, Takashi Kamiya, Yoshitoshi Ohtsuka, Noriko Ichimura, Yoshiaki Tsujino, Makiko Nakagawa, Fumiko Ohtsuki |
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| Rok vydání: | 1996 |
| Předmět: |
Male
Preleukemia CD33 Chronic myelomonocytic leukemia Lymphocyte Activation CD19 Antigens CD Bone Marrow hemic and lymphatic diseases Precursor cell Acute lymphocytic leukemia medicine Humans Induced pluripotent stem cell biology business.industry Infant Leukemia Myelomonocytic Chronic Hematology Precursor Cell Lymphoblastic Leukemia-Lymphoma medicine.disease medicine.anatomical_structure Immunology biology.protein Bone marrow business |
| Zdroj: | American Journal of Hematology. 52:212-214 |
| ISSN: | 1096-8652 0361-8609 |
| DOI: | 10.1002/(sici)1096-8652(199607)52:3<212::aid-ajh14>3.0.co;2-h |
| Popis: | A 10-month-old infant with chronic myelomonocytic leukemia (CMML) of 5 months' duration, who had been treated only with transfusion, displayed leukemic transformation characterized by lymphoid morphology, PAS positivity, and myeloperoxidase negativity. Surface marker analysis of blast cells revealed expression of lymphoid-associated antigens (CD10 and CD19) but not myeloid-associated antigens (CD13, CD14, and CD33). These findings suggest that some cases of infantile CMML are clonal disorders arising in a pluripotent stem cell that can also differentiate along the lymphoid cell lineage. |
| Databáze: | OpenAIRE |
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