Prospective Comparison of Eubacterial PCR and Measurement of Procalcitonin Levels with Blood Culture for Diagnosing Septicemia in Intensive Care Unit Patients
| Autor: | A Mehta, Camilla Rodrigues, Minal Deshmukh, Vinay R. Joshi, Farjana B. Rowther, Ashit Hegde, Farhad N Kapadia |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
Calcitonin DNA Bacterial Male Microbiology (medical) medicine.medical_specialty Adolescent Calcitonin Gene-Related Peptide Polymerase Chain Reaction Sensitivity and Specificity Procalcitonin law.invention Sepsis Young Adult Predictive Value of Tests law Intensive care Positive predicative value Internal medicine medicine Humans Blood culture Protein Precursors Aged Aged 80 and over Bacteria medicine.diagnostic_test business.industry Bacteriology Gold standard (test) Middle Aged bacterial infections and mycoses medicine.disease Intensive care unit Surgery Intensive Care Units Predictive value of tests Female business |
| Zdroj: | Journal of Clinical Microbiology. 47:2964-2969 |
| ISSN: | 1098-660X 0095-1137 |
| DOI: | 10.1128/jcm.00418-07 |
| Popis: | Rapid identification of infection has a major impact on the clinical course, management, and outcome of critically ill intensive care unit (ICU) patients. We compared the results of PCR and procalcitonin with blood culture for ICU patients suspected of having septicemia. Ninety patients (60 patients meeting the criteria for sepsis and 30 patients not meeting the criteria for sepsis) were evaluated. Compared with blood culture as the gold standard, the sensitivity, specificity, and positive and negative predictive values for PCR were 100%, 43.33%, 46.87%, and 100%, respectively, and for procalcitonin were 100%, 61.66%, 56.6%, and 100%, respectively. The average times required to produce a final result were as follows: PCR, 10 h; blood culture, 33 h; procalcitonin, 45 min. Both PCR and procalcitonin may be useful as rapid tests for detecting septicemia but compared with blood cultures lacked specificity. |
| Databáze: | OpenAIRE |
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