Adaptive response to chromosome damage in cultured human lymphocytes primed with low doses of X-rays
| Autor: | Masao S. Sasaki, Z.-Q. Wang, S. Saigusa |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Time Factors
DNA Repair DNA repair Health Toxicology and Mutagenesis Lymphocyte Priming (immunology) Sister chromatid exchange In Vitro Techniques Biology Resting Phase Cell Cycle Chromosome aberration Chromosomes Genetics medicine Humans Lymphocytes Molecular Biology Chromosome Aberrations X-Rays G1 Phase Chromosome Karyotype Cell cycle Adaptation Physiological Molecular biology medicine.anatomical_structure Immunology Sister Chromatid Exchange |
| Zdroj: | Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 246:179-186 |
| ISSN: | 0027-5107 |
| DOI: | 10.1016/0027-5107(91)90120-d |
| Popis: | Human lymphocytes exposed to 0.02 Gy of X-rays in the G1 but not the G0 phase became less susceptible to the induction of chromosome aberrations of the chromosome type by subsequent exposure to 3 Gy of X-rays. The induction of chromatid-type aberrations was not affected by the pretreatment with the priming dose. The expression of this adaptive-type response was transitory, being maximum at 5 h, and disappeared at 9 h after the initial low-dose exposure. Cell-cycle analysis excluded the possibility of a spurious consequence of differential cell-cycle progression. |
| Databáze: | OpenAIRE |
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