Effects of dipyridamole on peritoneal clearances
| Autor: | Zbylut J. Twardowski, Young M, K D Nolph, Gloor H, Sorkin Mi, Moore H, Reams Gp |
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| Rok vydání: | 1985 |
| Předmět: |
Adult
Male medicine.medical_treatment Placebo Peritoneal dialysis Double blind study Random Allocation Double-Blind Method Oral administration medicine Humans Dialysis Aged Clinical Trials as Topic business.industry Peritoneal fluid General Medicine Dipyridamole Middle Aged Nephrology Anesthesia Female Dialisis peritoneal Peritoneum business Peritoneal Dialysis medicine.drug |
| Zdroj: | Uremia investigation. 9(1) |
| ISSN: | 0740-1353 |
| Popis: | To see if oral dipyridamole increases peritoneal clearances in humans undergoing peritoneal dialysis, two types of double-blind clinical studies were undertaken. In a single-dose study, 7 patients were randomized to take dipyridamole or placebo early in a peritoneal dialysis with 2 L, hourly cycles; later in the same dialysis a crossover administration was studied. In a multidose study, 17 patients were randomized to take dipyridamole or placebo three times daily and clearance studies were performed on days 1, 4, and 8 during 2 L, hourly peritoneal dialysis cycles. Neither the single dose of dipyridamole or placebo significantly altered drainage volumes, clearances, or dialysate protein from control periods. In the multidose study, mean values on dipyridamole or placebo were not significantly changed from respective baseline predrug values. Mean values with dipyridamole and placebo usually were not significantly different. Dipyridamole did not appear to improve peritoneal clearances even with repeated ingestion. |
| Databáze: | OpenAIRE |
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