PET Study of [18F]6-Fluoro-l -Dopa Uptake in Neuroleptic- and Mood-Stabilizer-Naive First-Episode Nonpsychotic Mania: Effects of Treatment With Divalproex Sodium
| Autor: | Gayle Scarrow, Vesna Sossi, Thomas J. Ruth, Peter F. Liddle, Miguel Imperial, Jon Stoessl, Elton T.C. Ngan, Raymond W. Lam, Lakshmi N. Yatham, I-Shin Shiah |
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| Rok vydání: | 2002 |
| Předmět: |
Adult
Male Fluorine Radioisotopes medicine.medical_specialty Bipolar Disorder Bipolar I disorder medicine.drug_class Dopamine Striatum behavioral disciplines and activities Internal medicine mental disorders medicine Humans Bipolar disorder First episode Valproic Acid Dopaminergic Age Factors Mood stabilizer Middle Aged medicine.disease Corpus Striatum Dihydroxyphenylalanine Psychiatry and Mental health Endocrinology Anticonvulsants Female medicine.symptom Psychology Mania Neuroscience Antipsychotic Agents Tomography Emission-Computed medicine.drug |
| Zdroj: | American Journal of Psychiatry. 159:768-774 |
| ISSN: | 1535-7228 0002-953X |
| DOI: | 10.1176/appi.ajp.159.5.768 |
| Popis: | Although dopaminergic hyperactivity has been implicated in mania, the precise location in the brain of the abnormality is unclear. This study assessed presynaptic dopamine function in neuroleptic- and mood-stabilizer-naive nonpsychotic first-episode manic patients before and after treatment with divalproex sodium by measuring [(18)F]6-fluoro-L-dopa ([(18)F]DOPA) uptake in the striatum with positron emission tomography (PET).Thirteen patients with DSM-IV bipolar I disorder, manic episode, and 13 healthy comparison subjects underwent [(18)F]DOPA PET scans. Ten of the 13 patients had repeat PET scans 2-6 weeks after beginning treatment with divalproex sodium monotherapy. [(18)F]DOPA uptake rate constants (K(i) values) in the striatum were calculated by using graphical analysis with activity from the occipital cortex as the input function.No significant differences in [(18)F]DOPA uptake rate constants in the striatum were found between the manic patients and the comparison subjects. After treatment with divalproex sodium, [(18)F]DOPA rate constants were significantly reduced in the patients and were lower in the patients than in the comparison subjects.Although presynaptic dopamine function as reflected by [(18)F]DOPA uptake is not altered in mania, presynaptic dopamine function in manic patients was lower after treatment with divalproex sodium. |
| Databáze: | OpenAIRE |
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