Clinical and histopathological evaluation of 50 acantholytic cutaneous squamous cell carcinomas: Analysis outcome in a retrospective case‐control study
| Autor: | Javier Cañueto, David Revilla-Nebreda, Alberto Conde-Ferreirós, Angel Santos-Briz, Concepción Román-Curto, David Moyano-Bueno, Leonor Revelles-Peñas, Sara Becerril-Andrés |
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| Přispěvatelé: | Instituto de Salud Carlos III |
| Rok vydání: | 2021 |
| Předmět: |
Male
Pathology medicine.medical_specialty Skin Neoplasms Histology Cell Dermatology Skincancer Acantholytic squamous cell carcinoma Pathology and Forensic Medicine Infiltrative Growth Pattern Interquartile range medicine Humans Retrospective Studies Aged 80 and over Tumor size business.industry Acantholysis Case-control study Margins of Excision Cutaneous squamous cell carcinoma Prognosis medicine.disease medicine.anatomical_structure Case-Control Studies Lymphatic Metastasis Cohort Carcinoma Squamous Cell Female Neoplasm Recurrence Local Skin cancer business |
| Zdroj: | Digital.CSIC. Repositorio Institucional del CSIC instname |
| ISSN: | 1600-0560 0303-6987 |
| Popis: | [Background]: Acantholytic cutaneous squamous cell carcinomas (aCSCCs) have been classically considered as a high-risk variant of CSCC. However, more recent studies show that aCSCC does not confer more aggressiveness. This study aims to establish whether the prognosis of the aCSCC is worse than that of the non-acantholytic (naCSCC) or not. [Methods]: Retrospective case-control study with 50 aCSCCs and 50 naCSCCs. For each aCSCC, an naCSCC with similar high-risk features to the aCSCC but with no acantholysis was selected. Prognosis between both groups was compared. [Results]: The mean age was 86 years (SD 9.61). Sixty-one patients were men. Thirty-nine CSCCs were located in high-risk head and neck areas. Twenty CSCCs exhibited a poor degree of differentiation, and 36 showed an infiltrative growth pattern. The tumor diameter was 18.71 mm (interquartile range, IQR 35), and the tumor thickness was 6.72 mm (IQR 15.50). Twelve CSCCs exhibited perineural infiltration, and eight CSCCs exhibited invasion beyond the subcutaneous fat. Positive margins after excision of the tumor in 22 aCSCCs vs eight naCSCCs (P Instituto de Salud Carlos III, Grant/Award Number: PI18/000587 |
| Databáze: | OpenAIRE |
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