In Vitro Pharmacokinetic and Pharmacodynamic Evaluation of S-013420 against Haemophilus influenzae and Streptococcus pneumoniae
| Autor: | Shogo Kuwahara, Tomoyuki Homma, Merime Ohshiro, Yoshinori Yamano, Hideki Maki, Jingoro Shimada, Toshihiko Hori |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Pharmacology
Molecular Structure biology Cmax Microbial Sensitivity Tests biology.organism_classification Streptococcaceae medicine.disease_cause Haemophilus influenzae Anti-Bacterial Agents Microbiology Streptococcus pneumoniae Infectious Diseases Pharmacokinetics Pharmacodynamics Haemophilus medicine Pharmacology (medical) Antibacterial activity |
| Zdroj: | Antimicrobial Agents and Chemotherapy. 54:4300-4305 |
| ISSN: | 1098-6596 0066-4804 |
| DOI: | 10.1128/aac.00214-10 |
| Popis: | The pharmacokinetic (PK)/pharmacodynamic (PD) parameters and the antibacterial activity of S-013420, a novel bicyclolide, against Haemophilus influenzae and Streptococcus pneumoniae , including macrolide-resistant isolates, were investigated using an in vitro PD model. Various time-concentration curves were artificially constructed by modifying the PK data obtained in phase I studies. The activity against H. influenzae was evaluated using two parameters, that is, the area above the killing curve (AAC) and the viable cell reduction at 24 h. The relationships between the antibacterial activity of S-013420 and the three PK/PD parameters were investigated by fitting the data to the sigmoid maximum effective concentration model. The square of the correlation coefficient ( R 2 ) values for AAC versus the area under the concentration-time curve from 0 to 24 h (AUC 0-24 )/MIC, the peak concentration ( C max )/MIC, and the cumulative percentage of a 24-h period that the drug concentration exceeded the MIC under steady-state PK conditions (% T MIC ) were 0.92, 0.87, and 0.49, respectively. The R 2 values for viable cell reduction at 24 h versus AUC 0-24 /MIC, C max /MIC, and % T MIC were 0.93, 0.61, and 0.56, respectively. These results demonstrated that AUC 0-24 /MIC is the most significant parameter for evaluation of the antibacterial activity of S-013420. The values of AUC 0-24 /MIC required for maximum and static efficacy were 10.8 and 9.63, respectively, for H. influenzae and 16.3 to 22.3 and 4.66 to 9.01, respectively, for S. pneumoniae . This analysis is considered useful for determining the AUC value at the infection site, which would be required for efficacy in clinical use. |
| Databáze: | OpenAIRE |
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