Distribution of radioactive aerosol in the airways of children and adolescents with bronchial hyper-responsiveness
| Autor: | Jann Mortensen, Vibeke Backer |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Vital capacity
medicine.medical_specialty Adolescent Physiology Respiratory System Internal medicine Forced Expiratory Volume medicine Distribution (pharmacology) Humans Respiratory system Child Radionuclide Imaging Lung Technetium Tc 99m Aggregated Albumin Asthma Aerosols Inhalation business.industry Respiratory disease Krypton Radioisotopes General Medicine respiratory system medicine.disease Peripheral Respiratory Function Tests medicine.anatomical_structure Anesthesia Cardiology Bronchial Hyperreactivity business |
| Zdroj: | Clinical physiology (Oxford, England). 12(5) |
| ISSN: | 0144-5979 |
| Popis: | The purpose of this study was to examine the relationship between the pulmonary distribution of inhaled radioaerosol, bronchial responsiveness, and lung function in children and adolescents. The participating subjects (n = 39) were divided into three groups: (1) 14 asthmatics with bronchial hyper-responsiveness (BHR), (2) five non-asthmatic subjects with BHR, and (3) 20 controls without BHR. Pulmonary distribution of [99Tcm) albumin radioaerosol, maximal expiratory flow when 25% of forced vital capacity remain to be exhaled (MEF25), and bronchial responsiveness to inhaled histamine were measured. Twenty subjects (52%) had irregular central distribution and 19 subjects (48%) had regular distribution of radioaerosol in their lungs. No difference in distribution of radioaerosol was found between the three groups of children. The median MEF25 among non-asthmatic subjects (80% predicted) was lower than that found in controls (92% predicted) but higher than that found in asthmatic subjects (55% predicted). A relationship was found between reduced flow at the peripheral airways, as indicated by MEF25 and the degree of central distribution of radioaerosol. Furthermore, subjects with irregular central distribution of radioaerosol had an increased degree of bronchial responsiveness. In conclusion, children and adolescents who have flow rates in the peripheral airways or increased degree of bronchial responsiveness tend to have abnormal distribution of radioaerosols. |
| Databáze: | OpenAIRE |
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