Comparison of multiple quantitative MRI parameters for characterization of the goat cartilage in an ongoing osteoarthritis: dGEMRIC, T1ρ and sodium

Autor: Lars Rackwitz, Daniel Weber, Ulrich Nöth, Kathrin Hemberger, Daniel Haddad, Jakob Kreutner, Gunthard Lykowsky, Joachim H. X. Schrauth, Peter M. Jakob
Jazyk: angličtina
Předmět:
Cartilage
Articular
Pathology
medicine.medical_specialty
MRT
Knorpel
Sodium
Biophysics
Contrast Media
chemistry.chemical_element
Adipose tissue
Gadolinium
Osteoarthritis
präklinische Studie
Sensitivity and Specificity
030218 nuclear medicine & medical imaging
03 medical and health sciences
0302 clinical medicine
In vivo
preclinical study
Image Interpretation
Computer-Assisted
Animals
Medicine
Arthrose
Tissue Distribution
Radiology
Nuclear Medicine and imaging
cartilage
030203 arthritis & rheumatology
Radiological and Ultrasound Technology
medicine.diagnostic_test
business.industry
Goats
Cartilage
Reproducibility of Results
Delayed Gadolinium Enhanced Magnetic Resonance Imaging of Cartilage
Magnetic resonance imaging
medicine.disease
Magnetic Resonance Imaging
Molecular Imaging
medicine.anatomical_structure
chemistry
Radiology Nuclear Medicine and imaging
Sodium MRI
Female
business
Biomarkers
MRI
Zdroj: Zeitschrift für Medizinische Physik. (3):270-282
ISSN: 0939-3889
DOI: 10.1016/j.zemedi.2015.11.004
Popis: Rationale and Objectives Osteoarthritis (OA) is a degenerative joint disease leading to cartilage deterioration by loss of matrix, fibrillation, formation of fissures, and ultimately complete loss of the cartilage surface. Here, three magnetic resonance imaging (MRI) techniques, dGEMRIC (delayed Gadolinium enhanced MRI of cartilage; dG 1 =T 1,post ; dG 2 =1/T 1,post -1/T 1,pre ), T 1ρ ,and sodium MRI, are compared in a preclinical in vivo study to evaluate the differences in their potential for cartilage characterization and to establish an examination protocol for a following clinical study. Materials and Methods OA was induced in 12 caprine knees (6 control, 6 therapy). Adipose derived stem cells were injected afterwards as a treatment. The animals were examined healthy, 3 and 16 weeks postoperatively with all three MRI methods. Using statistical analysis, the OA development and the degree of correlation between the different MRI methods were determined. Results A strong correlation was observed between the dGEMRIC indices dG 1 and dG 2 (r=–0.87) which differ only in considering or not considering the T 1 baseline. Moderate correlations were found between T 1ρ and dG 1 (r=0.55), T 1ρ and dG 2 (r=0.47) and at last, sodium and dG 1 (r=0.45). The correlations found in this study match to the biomarkers which the methods are sensitive to. Conclusion Even though the goat cartilage is significantly thinner than the human cartilage and even more in a degenerated cartilage, all three methods were able to characterize the cartilage over the whole period of time during an ongoing OA. Due to measurement and post processing optimizations, as well as the correlations detected in this work, the overall measurement time in future goat studies can be minimized. Moreover, an examination protocol for characterizing the cartilage in a clinical study was established.
Databáze: OpenAIRE
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