Fatal Intoxication Due to Brucine
| Autor: | Jens-Peter Weller, Urs-Vito Albrecht, Jörg Teske, A. Fieguth |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Male
Health Toxicology and Mutagenesis Urine Toxicology High-performance liquid chromatography Poisons Analytical Chemistry chemistry.chemical_compound Fatal Outcome Blood serum Limit of Detection Diagnosis medicine Humans Environmental Chemistry Solid phase extraction Chemical Health and Safety Brucine Chromatography Poisoning Gallbladder Solid Phase Extraction Strychnine Middle Aged Suicide medicine.anatomical_structure chemistry Female Quantitative analysis (chemistry) |
| Popis: | A sensitive method for identifying and quantifying brucine by means of liquid chromatography-tandem mass spectrometry is presented in this article. Based on a solid-phase extraction for human serum, the validation indicated limits of detection and quantification of 0.12 and 0.23 ng/mL, respectively. In one case of lethal suicidal brucine monointoxication, brucine concentrations of 1.51 μg/mL, 1.69 μg/mL, 9.94 μg/mL, 16.4 μg/g, 0.99 μg/g, 0.75 μg/g, and 1.95 mg/g were determined in femoral blood, urine, bile collected from the gallbladder, liver tissue, cerebellum, cerebrum, and stomach contents, respectively. |
| Databáze: | OpenAIRE |
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