Recent Advances in the Treatment of Bone Metastases and Primary Bone Tumors: An Up-to-Date Review
| Autor: | Marius Radulescu, D. Rădulescu, Alexandru Mihai Grumezescu, Adrian Badila, Adrian Radu Rădulescu, Adelina-Gabriela Niculescu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Oncology
Cancer Research medicine.medical_specialty bone substitutes medicine.medical_treatment Review Bone tissue Internal medicine Medicine bone cancers RC254-282 Chemotherapy bone tumors business.industry Regeneration (biology) Neoplasms. Tumors. Oncology. Including cancer and carcinogens tissue-engineered scaffolds targeted therapies Tumor recurrence Radiation therapy Primary bone medicine.anatomical_structure Drug delivery drug delivery business Adjuvant |
| Zdroj: | Cancers Cancers, Vol 13, Iss 4229, p 4229 (2021) |
| ISSN: | 2072-6694 |
| Popis: | Simple Summary Bone represents a common metastatic site for patients with advanced cancers while also being associated with rare but challenging primary tumors. As the treatment of bone sarcomas and metastases encountered a slowdown in its development, complementary and alternative strategies to conventional therapies started being investigated. In this respect, this paper proposes a comprehensive path, beginning with the types of bone tumors and current treatment options, and further detailing the recent advancements in the field, including adjuvant therapies, targeted drug delivery, novel bone substitutes, and multifunctional tissue-engineered scaffolds with synergic properties. Abstract In the last decades, the treatment of primary and secondary bone tumors has faced a slow-down in its development, being mainly based on chemotherapy, radiotherapy, and surgical interventions. However, these conventional therapeutic strategies present a series of disadvantages (e.g., multidrug resistance, tumor recurrence, severe side effects, formation of large bone defects), which limit their application and efficacy. In recent years, these procedures were combined with several adjuvant therapies, with different degrees of success. To overcome the drawbacks of current therapies and improve treatment outcomes, other strategies started being investigated, like carrier-mediated drug delivery, bone substitutes for repairing bone defects, and multifunctional scaffolds with bone tissue regeneration and antitumor properties. Thus, this paper aims to present the types of bone tumors and their current treatment approaches, further focusing on the recent advances in new therapeutic alternatives. |
| Databáze: | OpenAIRE |
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