Adipose Tissue Protein Glycoxidation is Associated with Weight‐Loss Potential

Autor: Albert Lecube, Jorge Juan Olsina Kissler, Juan Antonio Baena-Fustegueras, José C. E. Serrano, Carolina López-Cano, Enric Sánchez, Meritxell Martín-Gari, Alba Naudí, Manuel Portero-Otin, Helene Rassendren, Fernando Herrerías González, Anna Cassanyé, María Cruz de la Fuente‐Juárez
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Male
Glycosylation
Endocrinology
Diabetes and Metabolism
Medicine (miscellaneous)
Adipose tissue
Bariatric Surgery
Obesitat -- Cirurgia
Protein oxidation
Mice
0302 clinical medicine
Endocrinology
Weight loss
030212 general & internal medicine
Nutrition and Dietetics
Stomach
Middle Aged
medicine.anatomical_structure
Adipose Tissue
Marcadors bioquímics
Original Article
Obesity Biology and Integrated Physiology
Female
medicine.symptom
Oxidation-Reduction
Adult
medicine.medical_specialty
030209 endocrinology & metabolism
03 medical and health sciences
Young Adult
Internal medicine
Diabetes mellitus
Weight Loss
medicine
Animals
Humans
Obesity
Aged
Receiver operating characteristic
business.industry
Proteins
Metabolism
Original Articles
medicine.disease
Disease Models
Animal
Teixit adipós
business
Proteïnes
Biomarkers
Zdroj: Obesity (Silver Spring, Md.)
Repositorio Abierto de la UdL
Universitad de Lleida
Recercat. Dipósit de la Recerca de Catalunya
instname
Popis: Objective: This study aimed to characterize the differences in protein oxidation biomarkers in adipose tissue (AT) as an indicator of AT metabolism and bariatric surgery weight‐loss success. Methods: A human model, in which sixty‐five individuals with obesity underwent bariatric surgery, and a diet‐induced obesity animal model, in which animals were treated for 2 months with normocaloric diets, were analyzed to determine the associations between AT protein oxidation and body weight loss. Protein oxidative biomarkers were determined by gas chromatography/mass spectrometry in AT from human volunteers before the surgery, as well as 2 months after a diet treatment in the animal model. Results: The levels of carboxyethyl‐lysine (CEL) and 2‐succinocystein (2SC) in both visceral and subcutaneous AT before the surgery directly correlated with greater weight loss in both human and animal models. 2SC levels in subcutaneous AT greater than 4.7 × 106 μmol/mol lysine (95% CI: 3.4 × 106 to 6.0 × 106) may predict greater weight loss after bariatric surgery (receiver operating characteristic curve area = 0.8222; P = 0.0047). Additionally, it was observed that individuals with diabetes presented lower levels of CEL and 2SC in subcutaneous AT (P = 0.0266 and P = 0.0316, respectively) compared with individuals without diabetes. Conclusions: CEL and 2SC in AT are useful biomarkers of AT metabolism and predict the individual's ability to reduce body weight after bariatric surgery. This research was supported by the Spanish National Health Institute (Instituto de Salud Carlos III) Grant Number PI15/00332 and PI17/00134.
Databáze: OpenAIRE
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