Clinical significance of respiratory virus detection in patients with acute exacerbation of interstitial lung diseases

Autor: Masachika Fujiwara, Mitsuru Sada, Manami Inoue, Kosuke Ohkuma, Daisuke Kurai, Takuma Yokoyama, Miku Oda, Hajime Takizawa, Yukari Ogawa, Kojiro Honda, Takeshi Saraya, Masaki Tamura, Hirokazu Kimura, Takayasu Watanabe, Haruyuki Ishii, Masato Watanabe, Sunao Mikura
Rok vydání: 2018
Předmět:
Male
Short term mortality
Non-IPF interstitial lung disease
Exacerbation
Kaplan-Meier Estimate
Gastroenterology
Idiopathic pulmonary fibrosis
PCR
polymerase chain reaction
0302 clinical medicine
CTD
connective tissue disease
Japan
BALF
bronchoalveolar lavage fluid
Prospective Studies
030212 general & internal medicine
UIP
usual interstitial pneumonia
Connective Tissue Diseases
HMPV
human metapneumovirus
Virus detection
Aged
80 and over
medicine.diagnostic_test
Interstitial lung disease
ILDs
interstitial lung diseases
respiratory system
IIP
idiopathic interstitial pneumonia
humanities
HPIV
human parainfluenza viruses
Acute exacerbation
Virus Diseases
Acute Disease
Respiratory virus
Female
medicine.symptom
Bronchoalveolar Lavage Fluid
Pulmonary and Respiratory Medicine
medicine.medical_specialty
HRV
human rhinovirus
Article
03 medical and health sciences
Internal medicine
medicine
IPF
idiopathic pulmonary fibrosis
Humans
HHV
human herpes virus
Idiopathic Interstitial Pneumonias
Idiopathic interstitial pneumonia
Aged
business.industry
Sputum
CMV
cytomegalovirus
medicine.disease
respiratory tract diseases
HRSV
human respiratory syncytial virus
Pneumonia
IPF
Bronchoalveolar lavage
030228 respiratory system
Lung Diseases
Interstitial
business
Zdroj: Respiratory Medicine
ISSN: 0954-6111
DOI: 10.1016/j.rmed.2018.02.003
Popis: Background The impact of viral infections on acute exacerbations in idiopathic pulmonary fibrosis (IPF) and/or non-IPF interstitial lung disease (ILDs) has been scarcely described. Objectives To elucidate the frequency of virus infections in patients with IPF or non-IPF ILDs including idiopathic interstitial pneumonia (IIP) or connective tissue disease (CTD)-associated pneumonia, and its influence on their short-term mortality. Methods We prospectively enrolled adult patients with acute exacerbation of IPF and non-IPF ILDs who were admitted to the hospital during the last 3 years, and examined the respiratory samples obtained from nasopharyngeal, sputum, and bronchoalveolar lavage fluid. Results A total of 78 patients were identified, consisting of 27 patients with acute exacerbation of IPF and 51 patients with non-IPF ILDs (IIP: n = 27, CTD-associated IP: n = 24). Of all patients, 15 (19.2%) had viruses detected in their respiratory samples including the human herpesvirus 7 (HHV7; n = 4) and cytomegalovirus (CMV) plus HHV7 (n = 3). The proportion of virus infections in the IPF and non-IPF ILDs groups was comparable. The Kaplan-Meier survival curves over 60 days revealed a lower survival probability in the virus positive group (n = 15, 60%) than in the virus negative group (n = 60, 83.3%, p
Databáze: OpenAIRE
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