Pulmonary alveolar proteinosis in a kidney transplant: a rare complication of sirolimus
| Autor: | Huseyin Kadikoy, Wadi N. Suki, A. Osama Gaber, Michael A. Paolini, Abdul Abdellatif, Nabeel Anwar, Katafan Achkar, Roberto Barrios, Abdallah Jeroudi |
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| Rok vydání: | 2010 |
| Předmět: |
Graft Rejection
medicine.medical_specialty medicine.medical_treatment Pulmonary Alveolar Proteinosis Gastroenterology Tacrolimus Pulmonary function testing Recurrence Internal medicine medicine Humans Sirolimus Transplantation Lung business.industry Middle Aged equipment and supplies medicine.disease Kidney Transplantation female genital diseases and pregnancy complications Surgery surgical procedures operative medicine.anatomical_structure Nephrology Hemolytic-Uremic Syndrome Kidney Failure Chronic Female Hemodialysis Pulmonary alveolar proteinosis business Immunosuppressive Agents medicine.drug Kidney disease |
| Zdroj: | Nephrology Dialysis Transplantation. 25:2795-2798 |
| ISSN: | 1460-2385 0931-0509 |
| Popis: | Pulmonary alveolar proteinosis (PAP) has been associated with the immunosuppressant sirolimus in transplant patients. PAP is a progressive lung disease characterized by the accumulation of surfactant-like material in the lungs leading to decreased pulmonary function with shortness of breath and cough as common symptoms. We report a rare case of sirolimus-associated PAP in a kidney transplant recipient with a history of end-stage renal disease secondary to haemolytic uraemic syndrome (HUS) and review of the literature. Discontinuation of sirolimus and initiation of tacrolimus led to resolution of PAP without recurrence of HUS. |
| Databáze: | OpenAIRE |
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