The regulation of ion channels and transporters by glycolytically derived ATP
| Autor: | William A. Coetzee, Piyali Dhar-Chowdhury, Brian Malester, P. Rajacic |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Blood Glucose
Potassium Channels Calcium-Transporting ATPases Oxidative phosphorylation Mitochondrion Ion Channels Cellular and Molecular Neuroscience Insulin Secretion Animals Homeostasis Humans Insulin Glycolysis Molecular Biology Ion channel Ion transporter Pharmacology biology Cell Membrane Membrane Transport Proteins Cell Biology Proton Pumps Cell Compartmentation Cell biology Ion Exchange Metabolic pathway biology.protein Molecular Medicine Ligand-gated ion channel Sodium-Potassium-Exchanging ATPase ATP synthase alpha/beta subunits |
| Zdroj: | Cellular and Molecular Life Sciences. 64:3069-3083 |
| ISSN: | 1420-9071 1420-682X |
| Popis: | Glycolysis is an evolutionary conserved metabolic pathway that provides small amounts of energy in the form of ATP when compared to other pathways such as oxidative phosphorylation or fatty acid oxidation. The ATP levels inside metabolically active cells are not constant and the local ATP level will depend on the site of production as well as the respective rates of ATP production, diffusion and consumption. Membrane ion transporters (pumps, exchangers and channels) are located at sites distal to the major sources of ATP formation (the mitochondria). We review evidence that the glycolytic complex is associated with membranes; both at the plasmalemma and with membranes of the endo/sarcoplasmic reticular network. We examine the evidence for the concept that many of the ion transporters are regulated preferentially by the glycolytic process. These include the Na(+)/K(+)-ATPase, the H(+)-ATPase, various types of Ca(2+)-ATPases, the Na(+)/H(+) exchanger, the ATP-sensitive K(+) channel, cation channels, Na(+) channels, Ca(2+) channels and other channels involved in intracellular Ca(2+) homeostasis. Regulation of these pumps, exchangers and ion channels by the glycolytic process has important consequences in a variety of physiological and pathophysiological processes, and a better understanding of this mode of regulation may have important consequences for developing future strategies in combating disease and developing novel therapeutic approaches. |
| Databáze: | OpenAIRE |
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