| Autor: |
Preston H. Grantham, Nguyen-Ba-Giao, Elizabeth K. Weisburger, Letitia C. Mohan, Timothy Benjamin, Peter P. Roller |
| Rok vydání: |
1976 |
| Předmět: |
|
| Zdroj: |
European Journal of Cancer (1965). 12:227-235 |
| ISSN: |
0014-2964 |
| DOI: |
10.1016/0014-2964(76)90246-2 |
| Popis: |
The absorption, distribution and excretion of 6 -aminochrysene- 5 , 6 - 14 C were investigated in rats. The highest concentration of radioactivity in the organs at 48 hr after an i. p. dose were in the liver and kidneys. Only 12% of the administered radioactivity was recovered in the urine and 56% from the feces during a ten day period. Up to 42% of the dose was excreted in the bile during 48 hours. The major biliary metabolite of 6 -aminochrysene was the N-glucuronide of 6 -aminochrysene. 12 -Hydroxy- 6 -acetylaminochrysene was present in the urine as a glucuronide and in unconjugated form in the feces. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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