Melanocytes as Instigators and Victims of Oxidative Stress
| Autor: | Sancy A. Leachman, Zalfa A. Abdel-Malek, Laurent Marrot, Laurence Denat, Ana Luisa Kadekaro |
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| Rok vydání: | 2014 |
| Předmět: |
Vitiligo
Dermatology Biology Melanocyte medicine.disease_cause Biochemistry Antioxidants Article Melanin Mice Paracrine signalling medicine Animals Humans skin and connective tissue diseases Melanoma Molecular Biology Melanins chemistry.chemical_classification Reactive oxygen species integumentary system Epidermis (botany) Pigmentation Cell Biology Oxidants medicine.disease 3. Good health Gene Expression Regulation Neoplastic Oxidative Stress medicine.anatomical_structure chemistry Immunology Melanocytes Epidermis Reactive Oxygen Species Oxidation-Reduction Oxidative stress |
| Zdroj: | The Journal of investigative dermatology |
| ISSN: | 0022-202X |
| Popis: | Epidermal melanocytes are particularly vulnerable to oxidative stress owing to the pro-oxidant state generated during melanin synthesis, and to the intrinsic antioxidant defenses that are compromised in pathologic conditions. Melanoma is thought to be oxidative stress driven, and melanocyte death in vitiligo is thought to be instigated by a highly pro-oxidant state in the epidermis. We review the current knowledge about melanin and the redox state of melanocytes, how paracrine factors help counteract oxidative stress, the role of oxidative stress in melanoma initiation and progression and in melanocyte death in vitiligo, and how this knowledge can be harnessed for melanoma and vitiligo treatment. |
| Databáze: | OpenAIRE |
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