The use of AMD3100 plus G-CSF for autologous hematopoietic progenitor cell mobilization is superior to G-CSF alone
| Autor: | Karin Badel, Jane L. Liesveld, John M. McCarty, Scott D. Rowley, Neal Flomenberg, Gary Calandra, David H. Vesole, Steven M. Devine, John F. DiPersio |
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| Rok vydání: | 2005 |
| Předmět: |
Adult
Male medicine.medical_specialty Benzylamines Adolescent Immunology CD34 Antigens CD34 Pharmacology Cyclams Biochemistry Heterocyclic Compounds Internal medicine Antineoplastic Combined Chemotherapy Protocols Granulocyte Colony-Stimulating Factor medicine Autologous transplantation Humans CXC chemokine receptors Progenitor cell Aged business.industry Plerixafor Drug Synergism Cell Biology Hematology Middle Aged Hematopoietic Stem Cell Mobilization Granulocyte colony-stimulating factor Transplantation Endocrinology Female Stem cell business medicine.drug |
| Zdroj: | Blood. 106(5) |
| ISSN: | 0006-4971 |
| Popis: | Hematopoietic progenitor cells (HPCs) traffic to and are retained in the marrow through the trophic effects of the chemokine stromal cell-derived factor-1alpha (SDF-1alpha) binding to its receptor, CXC chemokine receptor 4 (CXCR4). AMD3100 reversibly inhibits SDF-1alpha/CXCR4 binding, and AMD3100 administration mobilizes CD34(+) cells into the circulation. We therefore tested the hypotheses that the combination of AMD3100 plus granulocyte colony-stimulating factor (G-CSF) (hereafter A + G) would be superior to G-CSF alone (hereafter G) in mobilizing hematopoietic progenitor cells (HPCs) and that A + G-mobilized cells would engraft as well as G-mobilized cells. The primary objective was to determine whether patients mobilized more progenitor cells per unit of blood volume of apheresis after A + G administration versus G alone. Secondary objectives were to determine whether patients mobilized with A + G compared with G alone required fewer apheresis procedures to reach the target level at least 5 x 10(6) CD34(+) cells/kg for transplantation and to determine whether patients mobilized with A + G had at least a 90% success rate of autologous transplantation as assessed by neutrophil engraftment by day 21. Each patient served as his or her own control in a sequential mobilization design. All study objectives were met without significant toxicity. The results demonstrate that the combination of A + G is generally safe, effective, and superior to G alone for autologous HPC mobilization. |
| Databáze: | OpenAIRE |
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