Rgs 2 gene polymorphisms as modulators of anxiety in humans?
| Autor: | Borwin Bandelow, Christa Hohoff, Jürgen Deckert, Jonathan Flint, Petra Krakowitzky, Petra Franke, A. Leygraf, Saffron A.G. Willis-Owen, Jürgen Fritze, Christine M. Freitag, Rolf Fimmers |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Single-nucleotide polymorphism
Anxiety Biology Polymorphism Single Nucleotide behavioral disciplines and activities Linkage Disequilibrium Genotype Odds Ratio medicine Humans Agoraphobia Biological Psychiatry RGS2 DNA Primers Psychiatric Status Rating Scales Genetics Reverse Transcriptase Polymerase Chain Reaction Panic disorder Haplotype medicine.disease Psychiatry and Mental health Neurology Chromosomes Human Pair 1 Case-Control Studies Knockout mouse Panic Disorder Neurology (clinical) medicine.symptom RGS Proteins |
| Popis: | Rgs2 (regulator of G-protein signalling 2) gene recently was reported as a quantitative trait gene for anxious behaviour in mice and male Rgs2 knockout mice have been shown to be more anxious than wildtype mice. Therefore we investigated four non-coding single nucleotide polymorphisms in a sample of 173 patients with panic disorder and 173 matched controls of German descent. At the genotype level all four SNPs were associated with panic disorder (p = 0.02-0.05). At the haplotype level the strongest association was observed for a haplotype containing SNP3 and SNP 4 (subgroup men and men with agoraphobia: p = 0.01 and 0.03). This points towards a functional polymorphism at the 3' end of the gene. Our results support the hypothesis that variations of the Rgs2 gene play a role also for the development of anxiety in humans. |
| Databáze: | OpenAIRE |
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