An exon variant in insulin receptor gene is associated with susceptibility to colorectal cancer in women
| Autor: | Hossein Nobakht, Maral Arkani, Reza Dabiri, Khatoon Karimi, Hamid Farahani, Negar Karimi, Keivan Majidzadeh-A, Mohammad Reza Zali, Touraj Mahmoudi, Hesamodin Dolatmoradi |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
endocrine system medicine.medical_specialty Genotype medicine.medical_treatment IGFBP3 Biology Insulin resistance Internal medicine medicine Humans Insulin Genetic Predisposition to Disease Insulin-Like Growth Factor I Aged Aged 80 and over Case-control study Genetic Variation General Medicine Exons Middle Aged medicine.disease IRS2 Receptor Insulin IRS1 Insulin receptor Endocrinology Insulin-Like Growth Factor Binding Protein 3 Case-Control Studies biology.protein Insulin Receptor Substrate Proteins Female Colorectal Neoplasms |
| Zdroj: | Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. 36(5) |
| ISSN: | 1423-0380 |
| Popis: | Given the role of insulin resistance in colorectal cancer (CRC), we explored whether genetic variants in insulin (INS), insulin receptor (INSR), insulin receptor substrate 1 (IRS1), insulin receptor substrate 2 (IRS2), insulin-like growth factor 1 (IGF1), and insulin-like growth factor binding protein 3 (IGFBP3) genes were associated with CRC risk. A total of 600 subjects, including 261 cases with CRC and 339 controls, were enrolled in this case-control study. Six polymorphisms in INS (rs689), INSR (rs1799817), IRS1 (rs1801278), IRS2 (rs1805097), IGF1 (rs5742612), and IGFBP3 (rs2854744) genes were genotyped using PCR-RFLP method. No significant difference was observed for INS, INSR, IRS1, IRS2, IGF1, and IGFBP3 genes between the cases and controls. However, the INSR rs1799817 “TT + CT” genotype and “CT” genotype compared with “CC” genotype occurred more frequently in the women with CRC than women controls (P = 0.007; OR = 1.93, 95 %CI = 1.20–3.11 and P = 0.002, OR = 2.15, 95 %CI = 1.31–3.53, respectively), and the difference remained significant after adjustment for confounding factors including age, BMI, smoking status, NSAID use, and family history of CRC (P = 0.018; OR = 1.86, 95 %CI = 1.11-3.10 and P = 0.004, OR = 2.18, 95 %CI = 1.28–3.71, respectively). In conclusion, to our knowledge, this study indicated for the first time that the INSR rs1799817 TT + CT genotype and CT genotype compared with the CC genotype had 1.86-fold and 2.18-fold increased risks for CRC among women, respectively. Furthermore, this finding is in line with previous studies which found significant associations between other variants of the INSR gene and CRC risk. Nevertheless, further studies are required to confirm our findings. |
| Databáze: | OpenAIRE |
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