The FAS-670 polymorphism influences susceptibility to multiple sclerosis
| Autor: | N. F. Kalkers, L.M.L. van Winsen, Peter Joseph Jongen, Frederik Barkhof, T. van Veen, B.M.J. Uitdehaag, Amado Salvador Peña, J.B.A. Crusius, Chris H. Polman |
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| Rok vydání: | 2002 |
| Předmět: |
Adult
Male Fas Ligand Protein Multiple Sclerosis Immunology DNA Mutational Analysis Lesion Sex Factors Gene Frequency Polymorphism (computer science) medicine Immunology and Allergy Humans Interferon gamma In patient Genetic Predisposition to Disease Genetic Testing fas Receptor Allele Age of Onset Membrane Glycoproteins Polymorphism Genetic business.industry Multiple sclerosis Brain Interferon-beta Middle Aged Fas receptor medicine.disease Magnetic Resonance Imaging Neurology Apoptosis Female Neurology (clinical) medicine.symptom business medicine.drug |
| Zdroj: | Journal of neuroimmunology. 128(1-2) |
| ISSN: | 0165-5728 |
| Popis: | Several studies have reported a defective Fas function in patients with multiple sclerosis (MS). We were interested whether this could result from a genetically altered Fas regulation. We examined the FAS 670 polymorphism in 382 patients with MS and 206 controls, and found that the carriership of allele FAS 670*G was significantly less frequent in patients than in controls. We found no association between the carriership of FAS 670*G and clinical features. For a subgroup of patients, longitudinal MRI data were available. We observed similar brain and lesion volumes in carriers and noncarriers of FAS 670*G. These data suggest that FAS 670*G decreases the risk of developing MS, but does not affect the course of disease. D 2002 Elsevier Science B.V. All rights reserved. |
| Databáze: | OpenAIRE |
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