Characterization of iron metabolism and erythropoiesis in erythrocyte membrane defects and thalassemia traits
| Autor: | Marian Hajduch, Zuzana Zidova, Jana Vrbkova, Lucie Sulovska, Monika Horvathova, Dusan Holub, Dagmar Pospisilova, Vladimír Mihál, Martina Divoka |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Iron metabolism disorder congenital hereditary and neonatal diseases and abnormalities Adolescent Iron Population lcsh:Medicine Spherocytosis Hereditary General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 0302 clinical medicine Hepcidins Hepcidin erythropoietic activity Internal medicine hemic and lymphatic diseases medicine Humans Erythropoiesis Child education Soluble transferrin receptor Analysis of Variance Hemostasis education.field_of_study biology medicine.diagnostic_test business.industry Erythrocyte Membrane lcsh:R Elliptocytosis Hereditary Ferritin 030104 developmental biology Endocrinology thalassemia trait Erythropoietin Child Preschool biology.protein Serum iron Thalassemia erythrocyte membrane defects hepcidin business 030215 immunology medicine.drug |
| Zdroj: | Biomedical Papers, Vol 160, Iss 2, Pp 231-237 (2016) |
| ISSN: | 1804-7521 1213-8118 |
| Popis: | Background and Aims. Erythropoiesis is closely related to iron metabolism in a balanced homeostasis. Analyses of diverse erythroid and iron metabolism disorders have shown that disrupted erythropoiesis negatively affects iron homeostasis and vice versa. The aim of this study was to characterize the relationship between erythropoietic activity and iron homeostasis in pediatric patients with erythrocyte membrane defects and thalassemia traits. Methods. Selected markers of erythropoietic activity (erythropoietin, soluble transferrin receptor - sTfR and growth differentiation factor 15) and iron status parameters (serum iron, ferritin and hepcidin) were evaluated in pediatric patients with erythrocyte membrane defects and thalassemia traits. Results. The patients with erythrocyte membrane defects and thalassemia traits had altered iron homeostasis due to disturbed erythropoiesis. In comparison with healthy controls, they had a normal to low hepcidin/ferritin ratio and concomitantly elevated sTfR. Conclusion. The findings suggest that pediatric patients with erythrocyte membrane defects and thalassemia traits are more susceptible to iron overload than the general population and that the (hepcidin/ferritin)/sTfR ratio can be used to monitor any worsening of the disease. |
| Databáze: | OpenAIRE |
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