Distribution patterns of intramyocellular and extramyocellular fat by magnetic resonance imaging in subjects with diabetes, prediabetes and normoglycaemic controls
| Autor: | Thierno D. Diallo, Mareen Sarah Kraus, Lena S. Kiefer, Wolfgang Rathmann, Jürgen Machann, Susanne Rospleszcz, Jana Fabian, Christa Meisinger, Fabian Bamberg, Margit Heier, Christopher L. Schlett, Roberto Lorbeer, Frank W. Roemer, Konstantin Nikolaou, Annette Peters, Corinna Storz |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Endocrinology Diabetes and Metabolism Population 030209 endocrinology & metabolism Type 2 diabetes 030204 cardiovascular system & hematology Gastroenterology Prediabetic State 03 medical and health sciences 0302 clinical medicine Endocrinology Diabetes mellitus Internal medicine Internal Medicine Humans Medicine Mass index ddc:610 Prediabetes Intramyocellular lipids Muscle Skeletal education education.field_of_study business.industry Middle Aged medicine.disease Lipids Magnetic Resonance Imaging Diabetes Mellitus Type 2 Body Composition Cohort Study Type 2 Diabetes Female Median body Intramuscular fat business human activities |
| Zdroj: | Diabetes Obes. Metab. 23, 1868–1878 (2021) |
| Popis: | AIM To evaluate the distribution of intramyocellular lipids (IMCLs) and extramyocellular lipids (EMCLs) as well as total fat content in abdominal skeletal muscle by magnetic resonance imaging (MRI) using a dedicated segmentation algorithm in subjects with type 2 diabetes (T2D), prediabetes and normoglycaemic controls. MATERIALS AND METHODS Subjects from a population-based cohort were classified with T2D, prediabetes or as normoglycaemic controls. Total myosteatosis, IMCLs and EMCLs were quantified by multiecho Dixon MRI as proton-density fat-fraction (in %) in abdominal skeletal muscle. RESULTS Among 337 included subjects (median age 56.0 [IQR: 49.0-64.0] years, 56.4% males, median body mass index [BMI]: 27.2 kg/m2 ), 129 (38.3%) were classified with an impaired glucose metabolism (T2D: 49 [14.5%]; prediabetes: 80 [23.7%]). IMCLs were significantly higher than EMCLs in subjects without obesity (5.7% [IQR: 4.8%-7.0%] vs. 4.1% [IQR: 2.7%-5.8%], P |
| Databáze: | OpenAIRE |
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