Psychophysics of Electrical Stimulation of Striate Cortex in Macaques
| Autor: | Barry B. Lee, Jeffrey D. Lewine, Nubio Negrão, Robert W. Doty, William H. Overman, John R. Bartlett, Edgar A. DeYoe |
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| Rok vydání: | 2005 |
| Předmět: |
Male
Behavior Animal Refractory Period Electrophysiological Physiology Deep Brain Stimulation General Neuroscience Long-Term Potentiation Differential Threshold Stimulation Electric Stimulation Refractory Period Psychological Microelectrode Psychophysics Animals Macaca nemestrina Striate cortex Psychology Evoked Potentials Neuroscience Psychomotor Performance Visual Cortex |
| Zdroj: | Journal of Neurophysiology. 94:3430-3442 |
| ISSN: | 1522-1598 0022-3077 |
| DOI: | 10.1152/jn.00406.2005 |
| Popis: | Macaques indicated their detection of onset or alteration of 0.2-ms pulses applied in various configurations through electrodes implanted in striate cortex. When microelectrodes were introduced and left in place, the threshold for detection of 100-Hz pulses nearly doubled within 24 h. However, for chronically implanted platinum-alloy macroelectrodes detection thresholds usually remained stable for many months, independently of location within striate cortex or its immediately subjacent white matter. Thresholds were unaffected by the visual conditions, such as light versus darkness, or movement of the eyes; but in one animal blind after acute glaucoma thresholds for loci in striate cortex were permanently decreased by about 50%. Learning to respond to electrical stimulation of the optic tract produced no tendency to respond to such stimulation of striate cortex. Onset of stimulation at a given locus could be detected even in the face of continuous supraliminal stimulation at four surrounding loci on a 3-mm radius. The surround stimulation did alter the threshold of the central locus, but such stimuli could not summate if they were subliminal by some 10%. Cessation of stimulation that had been continuing for 1 min to 1 h could be detected if it were being applied at a level 20–75% above that needed for detection of stimulus onset. Continuous stimulation had a pronounced “priming” effect, in that modulation of frequency or intensity of such stimulation by as little as 5% could be detected (e.g., 20 μA in a background of 500 μA, or |
| Databáze: | OpenAIRE |
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