Altered expression of synaptic proteins occurs early during progression of Alzheimer’s disease
| Autor: | Margaret Mallory, John C. Morris, Eliezer Masliah, Richard DeTeresa, Daniel W. McKeel, M. Alford, L. A. Hansen |
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| Rok vydání: | 2001 |
| Předmět: |
Pathology
medicine.medical_specialty Clinical Dementia Rating Immunoblotting Synaptophysin Nerve Tissue Proteins chemical and pharmacologic phenomena Severity of Illness Index Synaptotagmin 1 Synapse Synaptotagmins GAP-43 Protein Degenerative disease Alzheimer Disease Calcium-binding protein mental disorders medicine Humans Gap-43 protein Aged Aged 80 and over Membrane Glycoproteins biology Calcium-Binding Proteins medicine.disease Frontal Lobe nervous system Synapses Disease Progression biology.protein Neurology (clinical) Alzheimer's disease Psychology |
| Zdroj: | Neurology. 56:127-129 |
| ISSN: | 1526-632X 0028-3878 |
| Popis: | The expression levels of three synaptic proteins (synaptophysin, synaptotagmin, and growth-associated protein 43 [GAP43]) in AD cases clinically classified by Clinical Dementia Rating (CDR) score were analyzed. Compared with control subjects (CDR = 0), mild (early) AD (CDR = 0.5 to 1) cases had a 25% loss of synaptophysin immunoreactivity. Levels of synaptotagmin and GAP43 were unchanged in mild AD, but cases with CDR of >1 had a progressive decrement in these synaptic proteins. Thus, synaptic injury in frontal cortex is an early event in AD. |
| Databáze: | OpenAIRE |
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