The prevalence of corneal abnormalities in first-degree relatives of patients with keratoconus: a prospective case-control study
| Autor: | Ariela Gordon-Shaag, Joseph Frucht‐Pery, Edna Granit, Einat Shneor |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_specialty Keratoconus Visual acuity genetic structures Adolescent Scheimpflug principle Visual Acuity Cornea 03 medical and health sciences Young Adult 0302 clinical medicine Ophthalmology medicine Prevalence Humans genetics Family Prospective Studies First-degree relatives Israel Child Retinoscopy medicine.diagnostic_test business.industry Case-control study Corneal Topography Original Articles Middle Aged medicine.disease Corneal topography eye diseases Sensory Systems Case-Control Studies 030221 ophthalmology & optometry Etiology Original Article Female sense organs medicine.symptom business 030217 neurology & neurosurgery Optometry |
| Zdroj: | Ophthalmic & Physiological Optics |
| ISSN: | 1475-1313 |
| Popis: | Purpose Although there is a high prevalence of keratoconus in the Middle East including Israel, limited data is available describing first‐degree relatives of patients with sporadic keratoconus (KC) using Scheimpflug imaging. The purpose of this study is to accurately phenotype first‐degree relatives of patients with sporadic KC in Israel using corneal tomography, which may help determine the genetic aetiology of KC. Methods First‐degree relatives (N = 56) of 16 KC probands participated in this prospective case‐control study. Healthy controls (N = 96) were from a previous study. Autorefraction, visual acuity, slit lamp biomicroscopy, retinoscopy, subjective refraction and Scheimpflug imaging (CSO Sirius Topographer) of keratoconus patients and their first‐degree relatives were evaluated. The worse eye was used for KC and KC suspects. The main outcome measure was prevalence of abnormal corneal topography and tomography parameters, which was compared between first‐degree relatives vs controls. p values |
| Databáze: | OpenAIRE |
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