Decreased expression of the ATM gene linked to poor prognosis for gastric cancer of different nationalities in Xinjiang
| Autor: | Mei Han, Yong Tang, Lanying Ma, Yanli Qu |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Adult Male Poor prognosis China Normal tissue Down-Regulation Ataxia Telangiectasia Mutated Proteins Kaplan-Meier Estimate Adenocarcinoma Pathology and Forensic Medicine law.invention 03 medical and health sciences Young Adult 0302 clinical medicine law Stomach Neoplasms medicine Biomarkers Tumor Humans Polymerase chain reaction Aged Proportional Hazards Models Genetics Aged 80 and over business.industry Cancer Cell Biology Middle Aged medicine.disease Prognosis 030104 developmental biology Atm gene 030220 oncology & carcinogenesis Cancer research Clinicopathological features Immunohistochemistry Female business Transcriptome |
| Zdroj: | Pathology, research and practice. 213(8) |
| ISSN: | 1618-0631 |
| Popis: | To explore the clinicopathological significance of ATM gene in the occurrence and prognosis of gastric cancer (GC) from different nationalities in Xinjiang.The expression of ATM in 385 patients with GC (including 98 Uygurs, 231 Hans and 56 Kazaks) and its corresponding adjacent tissues were examined by quantitative real-time polymerase chain reaction (qRT-PCR) and immunohistochemistry assay to, analyze its correlations with clinicopathological features and prognosis of GC.The ATM expression in GC tissues was significantly decreased when compared to that in adjacent normal tissues of Uygur, Han and Kazak patients in Xinjiang, while Uygurs and Kazaks were much lower than Hans in the ATM expression of GC tissues (all P0.05). Kaplan-Meier analysis showed that Uygur and Kazak patients with ATM-negative tumors had a markedly lower survival rate than patients in Hans (P=0.028), and GC patients with ATM negative expression presented more unfavorable overall survival rate than those with positive expression among the three different nationalities (all P0.05). Multivariate Cox regression analysis revealed that nationality, ATM expression, TNM staging, depth of invasion, and lymph node metastasis were independent factors affecting the prognosis of GC patients in Xinjiang (all P0.05).ATM was downregulated in GC patients in Xinjiang, especially for Uygurs and Kazaks, which suggested ATM to be an independent indicator of prognosis for GC therapy. |
| Databáze: | OpenAIRE |
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