Immunization against gross malignant lymphoma with mouse cell lines chronically infected with non-oncogenic murine C-type viruses
Autor: | Marie-Genevieve Blanchard, Jung Koo Youn, Georges Barski |
---|---|
Rok vydání: | 1974 |
Předmět: |
Graft Rejection
Male C57BL/6 Lymphoma Clone (cell biology) Biology Virus Cell Line BALB/c Mice L Cells Antigen medicine Animals Neoplasm Antigens Viral Mice Inbred BALB C Mice Inbred C3H Cell-Free System General Medicine Fibroblasts biology.organism_classification medicine.disease Virology Mice Inbred C57BL Retroviridae Immunization Cell culture AKR murine leukemia virus Neoplasm Transplantation Spleen |
Zdroj: | European Journal of Cancer (1965). 10:491-496 |
ISSN: | 0014-2964 |
DOI: | 10.1016/0014-2964(74)90072-3 |
Popis: | Three in vitro mouse cell lines, chronically infected with non-oncogenic C-type viruses, were used for immunization of C57BL 6 mice against isograft of highly malignant Gross virus-induced lymphoma. The most effective immunizations were obtained with the 2 cell lines originating from C3H and BALB c mice respectively, showing high degree of Gross virus-induced surface antigen. A third cell line, derived from a clone of L cells and similarily infected with a C-type virus, had no immunizing capacity. Protection of mice was obtained only after inoculation with the living cells. Cell-free culture supernatants were inefficient. |
Databáze: | OpenAIRE |
Externí odkaz: |