Immunization against gross malignant lymphoma with mouse cell lines chronically infected with non-oncogenic murine C-type viruses

Autor: Marie-Genevieve Blanchard, Jung Koo Youn, Georges Barski
Rok vydání: 1974
Předmět:
Zdroj: European Journal of Cancer (1965). 10:491-496
ISSN: 0014-2964
DOI: 10.1016/0014-2964(74)90072-3
Popis: Three in vitro mouse cell lines, chronically infected with non-oncogenic C-type viruses, were used for immunization of C57BL 6 mice against isograft of highly malignant Gross virus-induced lymphoma. The most effective immunizations were obtained with the 2 cell lines originating from C3H and BALB c mice respectively, showing high degree of Gross virus-induced surface antigen. A third cell line, derived from a clone of L cells and similarily infected with a C-type virus, had no immunizing capacity. Protection of mice was obtained only after inoculation with the living cells. Cell-free culture supernatants were inefficient.
Databáze: OpenAIRE