Development of a continuous process for α-thio-β-chloroacrylamide synthesis with enhanced control of a cascade transformation
| Autor: | Valérie M Y Cacheux, Denis Lynch, Anita R. Maguire, Olga C. Dennehy, Benjamin J. Deadman, Stuart G. Collins, Humphrey A. Moynihan |
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| Rok vydání: | 2016 |
| Předmět: |
flow chemistry
Thio 010402 general chemistry 01 natural sciences 0305 Organic Chemistry Transformation (music) Full Research Paper lcsh:QD241-441 lcsh:Organic chemistry Organic chemistry lcsh:Science Flow chemistry Process strategy 010405 organic chemistry Continuous flow Chemistry Organic Chemistry cascade reactions Combinatorial chemistry 0104 chemical sciences Cascade Scientific method Cascade reactions lcsh:Q α-thio-β-chloroacrylamides |
| Zdroj: | Beilstein Journal of Organic Chemistry, Vol 12, Iss 1, Pp 2511-2522 (2016) Beilstein Journal of Organic Chemistry |
| Popis: | A continuous process strategy has been developed for the preparation of α-thio-β-chloroacrylamides, a class of highly versatile synthetic intermediates. Flow platforms to generate the α-chloroamide and α-thioamide precursors were successfully adopted, progressing from the previously employed batch chemistry, and in both instances afford a readily scalable methodology. The implementation of the key α-thio-β-chloroacrylamide casade as a continuous flow reaction on a multi-gram scale is described, while the tuneable nature of the cascade, facilitated by continuous processing, is highlighted by selective generation of established intermediates and byproducts. |
| Databáze: | OpenAIRE |
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