Association between immunoglobulin heavy-chain variable region mutational status and isolated favorable baseline genomic aberrations in chronic lymphocytic leukemia
| Autor: | Javier Pinilla-Ibarz, Chetasi Talati, Samir Dalia, Lisa Nodzon, Syeda Mahrukh Hussnain Naqvi, Julio C. Chavez, Jose D Sandoval-Sus, Mohamed A. Kharfan-Dabaja |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male Oncology Cancer Research medicine.medical_specialty Chronic lymphocytic leukemia Immunoglobulin Heavy Chain Variable Region Karyotype Immunoglobulin Variable Region Trisomy Article 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans Mutational status In Situ Hybridization Fluorescence Aged Neoplasm Staging Aged 80 and over Chromosomes Human Pair 12 medicine.diagnostic_test business.industry Genomics Hematology Middle Aged Prognosis medicine.disease Leukemia Lymphocytic Chronic B-Cell Survival Analysis 030220 oncology & carcinogenesis Mutation Immunology Female Good prognosis Immunoglobulin Heavy Chains IGHV@ business Biomarkers 030215 immunology Fluorescence in situ hybridization |
| Zdroj: | Leuk Lymphoma |
| ISSN: | 1029-2403 1042-8194 |
| DOI: | 10.1080/10428194.2017.1323271 |
| Popis: | Immunoglobulin heavy-chain variable region (IGHV) mutational status and karyotype abnormalities are important prognostic factors in chronic lymphocytic leukemia (CLL). The goal was to assess the impact of IGHV in CLL patients with isolated favorable genetic aberrations (del13q, trisomy 12, or negative fluorescence in situ hybridization [FISH]). We studied 273 CLL patients with both IGHV mutational status and cytogenetic information: 145 with isolated del13q 49 with sole trisomy 12 and 79 with negative FISH. After a median follow-up of 7.8 years, patients with del13q-unmutated IGHV had a shorter time to first treatment (TFT) (2.98 vs. 17.44 years; p |
| Databáze: | OpenAIRE |
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